Results 201 to 210 of about 5,319,582 (307)

CRISPR/Cas9-compatible plasmids enabling seven dominant genetic selection methods for the human fungal pathogen <i>Cryptococcus neoformans</i>. [PDF]

Microbiol Spectr
Boucher MJ, Madhani HD.
europepmc   +1 more source

Simultaneously genetic selection of wheat yield and grain protein quality in rice-wheat and soybean-wheat cropping systems through critical nitrogen efficiency-related traits. [PDF]

Front Plant Sci, 2022
Chen Y, Wang K, Chen H, Yang H, Zheng T, Huang X, Fan G.   +6 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A review of myostatin gene mutations: Enhancing meat production and potential in livestock genetic selection. [PDF]

Open Vet J
Ayuti SR, Lamid M, Warsito SH, Al-Arif MA, Lokapirnasari WP, Rosyada ZNA, Sugito S, Akmal M, Rimayanti R, Gangil R, Khairullah AR, Abuzahra M, Moses IB, Anggraini L.   +13 more
europepmc   +1 more source

Can Nitrogen Excretion of Dairy Cows Be Reduced by Genetic Selection for Low Milk Urea Nitrogen Concentration? [PDF]

Animals (Basel), 2021
Ariyarathne HBPC, Correa-Luna M, Blair H, Garrick D, Lopez-Villalobos N.   +4 more
europepmc   +1 more source

GENETIC AND SELECTION

Proceeding book, 2019
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The emergence and use of expanded carrier screening in gamete donation: A new form of repro-genetic selection. [PDF]

Bioethics
Hudson N, Herbrand C, Culley L.
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Review: Cross-breeding, advanced reproductive technologies, and genetic selection in twelve dairy production systems in Africa. [PDF]

Animal
Kathambi EK, Sonstegard TS, Larsen PA.
europepmc   +1 more source