Results 191 to 200 of about 5,319,582 (307)

Analysis of genetic selection at insulin receptor substrate-2 gene loci. [PDF]

J Diabetes Metab Disord, 2021
Yoshiuchi I.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Integrative Genomic and Metabolomic Analysis Identifies mQTLs Associated with Genetic Selection for Tenderness in Nellore Cattle. [PDF]

Metabolites
Valim JMBC, Herreira VLS, Gôngora ALDSM, Beltrão LCF, Santos ESPD, Oliveira BS, Pugliesi G, Santana MHA, Polizel GHG, Colnago LA, Ocampos FMM, Ramírez-Zamudio GD, Silva SL, Cônsolo NRB.   +13 more
europepmc   +1 more source

Genetic selection modulates feeding behavior of group-housed pigs exposed to daily cyclic high ambient temperatures. [PDF]

PLoS One, 2022
Fraga AZ, Hauschild L, Henrique Reis Furtado Campos P, Valk M, Zava Bello D, Kipper M, Andretta I.   +6 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Genetic Selection for Growth Rate Reshapes the Plasma Metabolome of Rabbit Does Derived from Vitrified Embryos: Insights into Nutrient Metabolism and Productive Efficiency. [PDF]

Vet Sci
Mateo-López J, Huertas-Herrera A, Toro-Manríquez M, Hedemann MS, Cortés-García C, Llobat L, Páez-Rosas D, Cambra-López M, Pascual JJ, Marín-García PJ.   +9 more
europepmc   +1 more source

High-Altitude Genetic Selection and Genome-Wide Association Analysis of Yield-Related Traits in Elymus sibiricus L. Using SLAF Sequencing. [PDF]

Front Plant Sci, 2022
Zhang Z, Zheng Y, Zhang J, Wang N, Wang Y, Liu W, Bai S, Xie W.   +7 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Climate-resilient genetic selection in cattle: Insights from resilience phenotypes of Fogera cattle under climate variabilities. [PDF]

Vet Anim Sci
Kassahun D, Tilahun M, Tesema Z, Meseret M, Lakew E, Tesfa A, Bitew A, Lakew M, Bimrow T, Ayalew M, Kebede A, Hunegnaw B, Adane A, Dagnaw D, Alemayehu M, Tarekegn GM.   +15 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source