Results 211 to 220 of about 1,755,519 (297)

Surgical Outcomes After Risk-Reducing Mastectomy Among BRCA1 and BRCA2 Carriers.

JAMA Netw Open
Wiberg R, Hägglund S, Numan Hellquist B, Rosén A, Idahl A, Mani M, Bajalica-Lagercrantz S, Ehrencrona H, Karlsson P, Loman N, Sund M, Swedish BRCA Study Group.   +11 more
europepmc   +1 more source

Mitochondrial DNA Modification in Assisted Reproduction: Concept to Practice-A Narrative Review. [PDF]

Int J Mol Sci
Mohsin MM, Azher M, Asghar F, Rahiman HH, Dube R, Kar SS, Bahutair SNM, Goud BKM, Kar SS.   +8 more
europepmc   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Beyond the tear: the enduring role of aortic pathology in the era of genomic medicine. [PDF]

Open Heart
Grewal N, Niessen HWM.
europepmc   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Celocentesis: Current Evidence and Future Directions. [PDF]

J Clin Med
Cecchini F, Visentin S, Giambona A, Vinciguerra M, Picciotto F, Andrisani A, Cassina M, Londero AP, Nicolaides K, Cosmi E.   +9 more
europepmc   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Investigation of the mechanisms underlying the development and evolution of the mammalian cerebrum using gyrencephalic ferrets. [PDF]

Front Cell Dev Biol
Yoshino M, Mosiagina AI, Sano D, Dei R, Yoshida M, Kawasaki H.   +5 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Beyond the Globe: Molecular Diagnostics of Optic Nerve, Orbital, and Adnexal Neoplasms. [PDF]

Transl Vis Sci Technol
Dankberg A, Yu G, Rodriguez FJ.
europepmc   +1 more source