Results 171 to 180 of about 1,972,073 (332)

Genetic factors in diabetes mellitus studied by the oral glucose tolerance test.

, 1965
G. S. Thompson
openalex   +1 more source

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Genetic–Testing Law Stirs Debate [PDF]

, 1992
Thomas Breck
openalex   +1 more source

Health Care Savings from Personalizing Medicine Using Genetic Testing: The Case of Warfarin [PDF]

Progress towards realizing a vision of personalized medicine - drugs and drug doses that are safer and more effective because they are chosen based on an individual's genetic makeup - has been slower than once forecast.
Lutter, Randall, McWilliam, Andrew, Nardinelli, Clark   +2 more
core   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

244 Novel respirable antisense oligonucleotide (RASON) approach to primary and metastatic human lung cancer: preliminary results in a model system employing spontaneous lung tumors in dogs

Journal for ImmunoTherapy of Cancer, 2020
Jonathan Nyce
doaj   +1 more source

The Genetic Control of Variance in Comb and Testes Weights of Young Male Chickens

, 1961
R. George Jaap, Marion W. Murray, Roger W. Temple   +2 more
openalex   +1 more source

Measwring and Testing Genetic Differentiation With Ordered Versus Unordered Alleles [PDF]

, 1996
Odile Pons, Rémy J. Petit
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Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Clinical Findings with Implications for Genetic Testing in Families with Clustering of Colorectal Cancer [PDF]

, 1998
Juul Wijnen, Hans F. A. Vasen, P. Meera Khan, Aeilko H. Zwinderman, Heleen van der Klift, Adri Mulder, Carli M.J. Tops, Pål Møller, Riccardo Fodde, Fred H. Menko, Babs G. Taal, Fokko M. Nagengast, Han G. Brunner, Jan H. Kleibeuker, Rolf H. Sijmons, Gerrit Griffioen, Annette Bröcker‐Vriends, Egbert Bakker, Inge van Leeuwen‐Cornelisse, Anne Meijers-Heijboer, Dick Lindhout, Martijn H. Breuning, Jan G. Post, C. Schaap, Jaran Apold, Ketil Heimdal, Lucio Bertario, Marie Luise Bisgaard, P Goetz   +28 more
openalex   +1 more source