Results 181 to 190 of about 1,824,368 (348)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

The Effects of Two Stage Selection Based on Performance and Progeny Testing on the Genetic Gains

, 1984
Fumio Mukai, Kayo KITAYAMA, Toyokazu Fukushima   +2 more
openalex   +2 more sources

Genetic Testing for Breast Cancer Predisposition in 1999: Which Molecular Strategy and which Family Criteria? [PDF]

, 1999
Dominique Stoppa‐Lyonnet, Maria A. Caligo, Diana Eccles, D. Gareth Evans, N. E. Haites, N. S. Hodgson, Pål Møller, P. J. Morrison, C. M. Steel, Hans F. A. Vasen, Jenny C. Chang   +10 more
openalex   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Genetic variation in blue spruce: A test of populations in Nebraska

, 1984
David F. Van Haverbeke
openalex   +2 more sources

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

The impact of a mainstream genetic testing pathway and socioeconomic factors on the uptake of germline genetic testing in breast cancer patients: results of the nationwide GENE-SMART study. [PDF]

Breast Cancer Res
Jong CL, Siesling S, Puts GCWM, Jager A, Ausems MGEM.   +4 more
europepmc   +1 more source

Studies on the Genetic Variations of Gc Protein and Post-Albumin Protein in Horse Sera and their Usefullness for Parentage Test

, 1981
Masao Kuwajima, Kazushige Mogi, Tatsuo HOSODA, Tsuneo ABE   +3 more
openalex   +2 more sources

Clinical Findings with Implications for Genetic Testing in Families with Clustering of Colorectal Cancer [PDF]

, 1998
Juul Wijnen, Hans F. A. Vasen, P. Meera Khan, Aeilko H. Zwinderman, Heleen van der Klift, Adri Mulder, Carli M.J. Tops, Pål Møller, Riccardo Fodde, Fred H. Menko, Babs G. Taal, Fokko M. Nagengast, Han G. Brunner, Jan H. Kleibeuker, Rolf H. Sijmons, Gerrit Griffioen, Annette Bröcker‐Vriends, Egbert Bakker, Inge van Leeuwen‐Cornelisse, Anne Meijers-Heijboer, Dick Lindhout, Martijn H. Breuning, Jan G. Post, C. Schaap, Jaran Apold, Ketil Heimdal, Lucio Bertario, Marie Luise Bisgaard, P Goetz   +28 more
openalex   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source