Results 221 to 230 of about 1,948,626 (333)

Genetic testing predicts appearance but not behavior in dogs. [PDF]

Proc Natl Acad Sci U S A
Lord KA, Sohrab V, Bryc K, White ME, Kenney B, Morrill Pirovich K, Chen FL, Karlsson EK.   +7 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Comprehensive Genetic Testing for Clinical Decision-Making in a Patient With Congenital Hyperinsulinism. [PDF]

Genet Res (Camb)
Begemann M, Boy JAT, Kraft F, Vossschulte H, Barthlen W, Kummer S, Orlikowsky T, Torosoglu A, Eggermann T, Kurth I, Elbracht M, Pappa A.   +11 more
europepmc   +1 more source

Technical Considerations for Blood RNA Sequencing in Genetic Testing: Evaluation of Globin Depletion Methods, Batch Effects, and Sample Types

Xinyi Lu, Yumeng Ma, Xiaomei Luo, Xiaoyan Huo, Jie Wang, Yi Liu, Huili Liu, Ting Xu, Qianfeng Zhao, Yongguo Yu, Yanjie Fan   +10 more
openalex   +1 more source

Establishing Standardized Criteria to Improve the Interpretation of Genetic Testing for Ocular Disorders

, 2021
Kristy Lee, Emily Place, Radha Ayyagari, Rui Chen, Kerry Goetz, Robert B. Hufnagel, Linda M. Reis, Susanne Roosing, Emmanuelle Souzeau, Patrick Yu‐Wai‐Man, Brian C. Mansfield, Janey L. Wiggs   +11 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Generation of quartet reference materials for preimplantation genetic testing for structural rearrangements. [PDF]

BMC Genomics
Sun N, Zhang W, Yu D, Zhang M, Zou Y, Dong X, Wang Y, Song N, Guo Y, Jiang C, Wang W, Kong L, Liang B, Fei J, Lu S, Peng Z, Yu T, Xiang J, Qu S.   +18 more
europepmc   +1 more source

Hidden translocation between 15qter and 18qter impressed during cycles of preimplantation genetic testing using linkage analyses and chromosome microarray subsequently verified by fluorescence in situ hybridization

Gwo-Chin Ma, Chi-Fang Lin, Wen-Hsiang Lin, Shun-Ping Chang, Dong-Jay Lee, Mei-Hui Lee, Yi-Shing Lin, Ming Chen   +7 more
openalex   +1 more source

Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study [PDF]

, 2019
Andrea Jorgensen, Clare Prince, Gail Fitzgerald, Anita Hanson, Jennifer Downing, Julia Reynolds, Jieying E. Zhang, Ana Alfirevic, Munir Pirmohamed   +8 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source