Results 241 to 250 of about 5,304,709 (301)

Genetic Testing in Inherited Retinal Disease: Current Strategies and Future Directions. [PDF]

J Pers Med
Kang S, Lam BL, Lee W, Berrocal AM, Gregori NZ, Mendoza-Santiesteban CE, Sengillo JD.   +6 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Preimplantation Genetic Testing and Embryo Mosaicism: A Critical Narrative Review of Clinical Outcomes and Controversies. [PDF]

Obstet Gynecol Int
Inoue D, Asada Y.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Low diagnostic yield of presurgical genetic testing in adult patients with epilepsy. [PDF]

Epilepsia
Jünemann C, Stuart A, Kaur N, Wiebe S, Jette N, Singh S, Borlot F, Knake S, Calgary Comprehensive Epilepsy Program Collaborators, Billie Au PY, Klein KM.   +10 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Awareness, Attitudes, and Expectations of Indian Cancer Patients and Their Caregivers on Hereditary Cancers and Genetic Testing at a Tertiary Cancer Centre in India. [PDF]

J Genet Couns
Pathak RS, Angre A, Talker J, Sarin R.
europepmc   +1 more source

Genetic testing practices among specialist physicians who treat prostate cancer Updated survey of Canadian practitioners. [PDF]

Can Urol Assoc J
Yip SM, Niazi T, Hamilton RJ, Kolinsky MP, Gotto GT, Hotte SJ, Ong M, Rendon RA, Ferrario C, Saad F, Chi KN, Antebi E, Ko J, Parimi S, Shayegan B, Malone S, Lavallée LT, Sulatycki E, Newell M, Zardan A, Morash C.   +20 more
europepmc   +1 more source

Knowledge, attitudes, and self-efficacy toward cancer genetic testing among Black women with and without breast cancer. [PDF]

Cancer Causes Control
Bertrand KA, Trevino-Talbot M, Ruderman M, Flynn M, Cabral HJ, Palmer JR, Wang C.   +6 more
europepmc   +1 more source

Update and recommendations on genetic testing for amyotrophic lateral sclerosis in clinical practice: a Brazilian expert view. [PDF]

Front Neurol
Sgobbi P, de Rezende Pinto WBV, Seneor DD, Orsini M, Chieia MAT, Oliveira ASB.   +5 more
europepmc   +1 more source