Results 221 to 230 of about 5,304,709 (301)

A prospective study of non-invasive prenatal screening technology in preimplantation genetic testing cycles. [PDF]

Front Med (Lausanne)
Yan H, Wang Y, Zhao M, Li R, Huang J.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Genetic testing fraud trends. [PDF]

J Law Biosci
Paradise J, Valentine A, Cherny S, Ramesh C.   +3 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Iterative genetic testing identifies <i>SAMHD1</i> deficiency caused by a homozygous balanced translocation. [PDF]

J Hum Immun
Baker PJ, Zhang Y, Bishop I, Cleveland ML, McAllan AL, Hollway GE, Vedururu R, Kumar A, Krishnaswamy R, Wan KL, Kaub PA, Brown EL, Narayanan DL, Deveson IW, CIRCA, AADRY, Gowdie P, Renton WD, Ojaimi S, Fennell AP, Masters SL.   +20 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Genetic Testing After Heart Transplantation Uncovers Heritable Disease and Drives Family Screening. [PDF]

JACC Adv
Moliner-Abós C, Cabrera Argaña D, Belmar Cliville D, Rivas S, Crespo-Leiro MG, Peña Hidalgo A, Garrido Gonzalez R, Martín Marín P, Gómez Molina M, Lorca R, Cárdenes León A, González Vilchez F, Rodriguez Arias JJ, Basurte Elorz M, Valverde M, Larrañaga-Moreira JM, Antunez-Ballesteros M, de Frutos F, Rivas-Lasarte M, Manuel Sobrino Márquez J, Garrido Bravo IP, Diaz Molina B, Acosta Calero C, Goena-Vives C, García-Álvarez A, Vilches S, Garcia Romero E, Gomez Bueno M, Garcia Pinilla JM, Alonso Fernandez V, Ochoa JP, de Antonio-Ferrer M, Rodriguez-Santiago B, Mirabet-Pérez S.   +33 more
europepmc   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Cross-border genetic testing

Orphanet Journal of Rare Diseases, 2010
Barton David
doaj   +1 more source