Results 251 to 260 of about 1,948,626 (333)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Can Prenatal Ultrasound and Genetic Testing Reliably Exclude Non-Isolated Clubfoot? [PDF]

Prenat Diagn
de Vries JM, Arduc A, van Leeuwen E, Tan-Sindhunata MB, Struijs P, Witbreuk M, Linskens IH, Pajkrt E.   +7 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Molecular pathogenesis of the schwannomatosis genes and genetic testing strategies. [PDF]

Fam Cancer
Smith MJ.
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Genetic testing for SCA27B in Korean multiple system atrophy. [PDF]

Brain
Laß J, Berselli M, Rioux D, Schaake S, Follett J, Bravo JE, Veit AD, Ronchetti W, Reiff SB, Huentelman MJ, Vuzman D, Bower P, Khurana V, Trinh J, Jeon B, Kim HJ, Farrer MJ.   +16 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Genetic counselors' perspectives and experiences with workplace genetic testing: Results of a national survey. [PDF]

Genet Med Open
Truhlar A, Charnysh E, Pal S, Reader JM, Hendy K, Feero WG, Ryan K, Vogle A, McCain S, Ferber RA, Furnival J, Lee C, Roberts JS, Uhlmann WR, Sanghavi K, INSIGHT @ Work Consortium.   +15 more
europepmc   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Genetic testing of common and rare variants in dementia patients from a memory clinic : Dementia-related genetic testing in memory clinic. [PDF]

Alzheimers Res Ther
de Rojas I, Hulsman M, Tesi N, van Spaendonk RML, van der Schaar J, Dijkstra JIR, van der Flier WM, van Ruissen F, Jansen PR, Reinders MT, van Haelst MM, Pijnenburg YAL, Fernandez MV, Ruiz A, Holstege HH, van der Lee SJ.   +15 more
europepmc   +1 more source