Results 1 to 10 of about 1,504,225 (383)

Biomimetic Peptides: A New Generation of Gene Transfer Vectors [PDF]

مجله دانشکده پزشکی اصفهان, 2022
Gene therapy is a new approach that aims to modify defective genes or intracellular expression of therapeutic proteins, and this depends on the use of high-efficiency gene transfer systems.
Hooman Mahmoudi Aznaveh, Maryam Nikkhah
doaj   +1 more source

A review of Genetic Etiology and Emerging Molecular Therapies for FSHD in Preclinical Studies [PDF]

Reviews in Clinical Medicine, 2021
Facioscapulohumeral muscular dystrophy is one of the most common musculoskeletal diseases with a considerable burden. Most of the affected individuals experience muscle weakness as the common muscular symptom.
Mohammad Reza Seyyed taghia, Reza Jafarzadeh Esfehani, Reza Boostani, Mohammad Shariati, Ariane Sadr Nabavi   +4 more
doaj   +1 more source

Interleukins, growth factors, and transcription factors are key targets for gene therapy in osteoarthritis: A scoping review

Frontiers in Medicine, 2023
ObjectiveOsteoarthritis (OA) is the most common degenerative joint disease, characterized by a progressive loss of cartilage associated with synovitis and subchondral bone remodeling.
Melanie Uebelhoer, Cécile Lambert, Juliane Grisart, Kilian Guse, Stanislav Plutizki, Yves Henrotin, Yves Henrotin, Yves Henrotin   +7 more
doaj   +1 more source

The First Homozygote Mutation c.499G>T (Asp167Tyr) in the RPE65 Gene Encoding Retinoid Isomerohydrolase Causing Retinal Dystrophy

Current Issues in Molecular Biology, 2022
RPE65, an abundant membrane-associated protein present in the retinal pigment epithelium (RPE), is a vital retinoid isomerase necessary for regenerating 11-cis-retinaldehyde from all-trans retinol in the visual cycle.
Mirjana Bjeloš, Ana Ćurić, Benedict Rak, Mladen Bušić, Biljana Kuzmanović Elabjer   +4 more
doaj   +1 more source

Translating the combination of gene therapy and tissue engineering for treating recessive dystrophic epidermolysis bullosa [PDF]

European Cells & Materials, 2018
The combination of gene therapy and tissue engineering is one of the most promising strategies for the treatment of recessive dystrophic epidermolysis bullosa (RDEB).
A Dakiw Piaceski, D Larouche, K Ghani, F Bisson, S Cortez Ghio, S Larochelle, VJ Moulin, M Caruso, L Germain   +8 more
doaj   +1 more source

Human Neural Stem Cells: Translational Research for Neonatal Hypoxic-Ischemic Brain Injury [PDF]

Neonatal Medicine, 2019
Neonatal hypoxic-ischemic (HI) brain injury is a major cause of neonatal mortality and long-term neurodevelopmental disabilities. Although promising neuroprotective interventions have been studied, the current management of HI brain injury has been ...
Jeong Eun Shin, Jungho Han, Joo Hee Lim, Ho Seon Eun, Kook In Park   +4 more
doaj   +1 more source

Serotonin tranporter methylation and response to cognitive behaviour therapy in children with anxiety disorders [PDF]

, 2014
Anxiety disorders that are the most commonly occurring psychiatric disorders in childhood, are associated with a range of social and educational impairments and often continue into adulthood.
A Bittner, A Caspi, A Heils, AN Simmons, B Freeman, CCY Wong, D Wang, DA Cole, DHM Bodden, DR Nyholt, EL Kinnally, EL Kinnally, I Ouellet-Morin, J Belsky, J Cohen, J Piacentini, JL Hudson, JT Walkup, K Karg, K Wilhelm, KJ Lester, KN Månsson, KP Lesch, M Davies, M Van Ameringen, MB Stein, MH van Ijzendoorn, MW Coolen, N Perroud, O Doehrmann, PA Jones, R Bogdan, R Jaenisch, R Lowe, R Yehuda, RA Philibert, RM Rapee, S Cartwright-Hatton, S Sen, SC Messer, SE Taylor, SRH Beach, TC Eley, TC Eley, TH Ollendick, TM Ball, U Lueken, VL Ives-Deliperi, WK Silverman   +48 more
core   +6 more sources

Management of genetic diseases: Present and future

Revista de la Facultad de Medicina Humana, 2021
Today, the number of genetic diseases is around 10000 conditions, affecting to 6%-8% of all populations. This review shows us how the discovery of genetic variants in our genome, this facilitated to know with precision about the mechanisms ...
Hugo Hernán Abarca Barriga, Milana Trubnykova, María del Carmen Castro Mujica   +2 more
doaj   +1 more source

In Vitro Synergistic Enhancement of Newcastle Disease Virus to 5-Fluorouracil Cytotoxicity against Tumor Cells

Biomedicines, 2016
Background: Chemotherapy is one of the antitumor therapies used worldwide in spite of its serious side effects and unsatisfactory results. Many attempts have been made to increase its activity and reduce its toxicity.
Ahmed M. Al-Shammari, Marwa I. Salman, Yahya D. Saihood, Nahi Y. Yaseen, Khansaa Raed, Hiba Kareem Shaker, Aesar Ahmed, Aseel Khalid, Ahlam Duiach   +8 more
doaj   +1 more source

Advancing Drug Resistance Research Through Quantitative Modeling and Synthetic Biology [PDF]

Frontiers in Bioengineering and Biotechnology, 8: 583415 (2020), 2020
Antimicrobial resistance is an emerging global health crisis that is undermining advances in modern medicine and, if unmitigated, threatens to kill 10 million people per year worldwide by 2050. Research over the last decade has demonstrated that the differences between genetically identical cells in the same environment can lead to drug resistance ...
arxiv   +1 more source