Results 31 to 40 of about 1,008,568 (216)

Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration [PDF]

, 2005
Background The genetic differences among HIV-1 subtypes may be critical to clinical management and drug resistance surveillance as antiretroviral treatment is expanded to regions of the world where diverse non-subtype-B viruses predominate.Methods and ...
Wynhoven, B, Cane, P, Holguin, A, Pedro Cahn, Maria Belen Bouzas, Africa Holguin, Luis F Brigido, Sirivichayakul, S, Anne-Mieke Vandamme, Camacho, R, Efron, B, Koya Ariyoshi, Grossman, Z, Robert W Shafer, Shafer, RW, Bouzas, MB, Brian Wynhoven, Ricardo Camacho, Jonathan N Weber, Harrigan, PR, Ariyoshi, K, Ana Patricia Carvalho, Rosangela Rodrigues, Rudich, H, Candice Pillay, Soares, MA, Katzenstein, DA, Vandamme, AM, Clarke, J, Lynn Morris, Snoeck, J, Soriano, V, Rodrigues, R, Brigido, LF, Wataru Sugiura, Praphan Phanuphak, Kantor, R, Sugiura, W, John Clarke, Jonathan M Schapiro, Rami Kantor, David A Katzenstein, Carvalho, AP, P Richard Harrigan, Patricia Cane, Phanuphak, P, Brad Efron, Pillay, D, Pillay, C, Sunee Sirivichayakul, Joke Snoeck, Cahn, P, Hagit Rudich, Schapiro, JM, Morris, L, Zehava Grossman, Amilcar Tanuri, Tanuri, A, Weber, JN, Vincent Soriano, Deenan Pillay, Marcelo A Soares   +61 more
core   +1 more source

Prenatal diagnosis and genetic etiology analysis of talipes equinovarus by chromosomal microarray analysis

BMC Medical Genomics, 2023
Background With the advancement of molecular technology, fetal talipes equinovarus (TE) is believed to be not only associated with chromosome aneuploidy, but also related to chromosomal microdeletion and microduplication.
Xiaorui Xie, Baojia Huang, Linjuan Su, Meiying Cai, Yuqin Chen, Xiaoqing Wu, Liangpu Xu   +6 more
doaj   +1 more source

Familial Ménière's disease: clinical and genetic aspects [PDF]

, 2009
Background and purpose:Mre's disease is not uncommon, with an incidence in Caucasians of about one in 2000. The incidence peaks in the fifth decade. Cases are usually isolated or sporadic, but in perhaps five per cent other family members are affected ...
Morrison, A W, Morrison, G A J, Bailey, M.E.S.   +2 more
core   +1 more source

Genetic and Genomic Landscape of Secondary and Therapy-Related Acute Myeloid Leukemia [PDF]

, 2020
A subset of acute myeloid leukemia (AML) arises either from an antecedent myeloid malignancy (secondary AML, sAML) or as a complication of DNA-damaging therapy for other cancers (therapy-related myeloid neoplasm, t-MN).
Alexandra Higgins, Mithun Vinod Shah
core   +1 more source

Hereditary Transthyretin-Related Amyloidosis: Genetic Heterogeneity and Early Personalized Gene Therapy [PDF]

, 2022
Point mutations of the transthyretin (TTR) gene are related with hereditary amyloidosis (hATTR). The number of people affected by this rare disease is only partially estimated.
Sturiale, Valentina, Bruno, Francesca, Concetta Federico, Francesca Bruno, Brancato, Desiree, Valentina Sturiale, Ketty Dugo, Salvatore Saccone, Desiree Brancato, Saccone, Salvatore, Dugo, Ketty, Federico, Concetta   +11 more
core   +1 more source

Gene-based therapeutics for rare genetic neurodevelopmental psychiatric disorders [PDF]

, 2022
We are in an emerging era of gene-based therapeutics with significant promise for rare genetic disorders. The potential is particularly significant for genetic central nervous system disorders that have begun to achieve Food and Drug Administration ...
Tauscher-Wisniewski, Sitra, Bönnemann, Carsten, Wang, Dan, Zoghbi, Huda Y, Buxbaum, Joseph D, Kleiman, Robin J, Davidson, Beverly L, Bradbury, Allison M, Shaywitz, Adam J, Sahin, Mustafa, Tifft, Cynthia J, Gray, Steven J, Gray-Edwards, Heather L, Gao, Guangping, Berry-Kravis, Elizabeth, Flotte, Terence R, Corcoran, Gavin R   +16 more
core   +2 more sources

Long-term comparative analysis of AAV9-mediated gene replacement therapies for spinal muscular atrophy in mice

Nature Communications
Spinal muscular atrophy (SMA) results from a deficiency of the survival motor neuron (SMN) protein. Zolgensma, an adeno-associated virus (AAV)-based SMN1 gene-replacement therapy, is approved for SMA, though its long-term efficacy and safety remain ...
Xiupeng Chen, Qing Xie, Sarah J. Nath, Mojiao Tang, Hong Ma, Yasemin Özgür Günes, Tapan Sharma, Hao Liu, Mengtian Cui, Ailing Du, Mengjia Lu, Sophia Y. Liu, Boonying Wassamon, Mengyao Xu, Joseph Yunxi Wu, Qin Su, Timothy P. Fitzgibbons, Jinghua Liu, Fang Wan, Veena Kumanan, Ran He, Yijie Ma, Jun Yang, Heather L. Gray-Edwards, Thomas L. Gallagher, Phillip W. L. Tai, Guangping Gao, Jun Xie   +27 more
doaj   +1 more source

Assessment of the frequency and association with morbidity of DNA markers in multinational administrative divisions based on indigenous population data (based on cardiovascular diseases)

Кардиоваскулярная терапия и профилактика
Information on morbidity is presented in statistical reports for the entire population of multinational subjects of Russia, but population Biobanks contain information on individual peoples.Aim.
E. V. Balanovskaya, A. Yu. Potanina, S. M. Koshel, D. S. Adamov, I. V. Evsyukov, A. L. Borisova, M. S. Pokrovskaya, A. N. Meshkov   +7 more
doaj   +1 more source

A theological consideration of ethical issues raised by human genetic manipulation, with particular reference to gene therapy [PDF]

, 1999
Human genetic manipulation is considered in terms of genetic testing and screening, gene therapy and enhancement, and reproductive cloning. Deontological and utilitarian approaches to ethical decision-making prove less than satisfactory.
Elkington, Audrey Anne
core  

Neuroimaging Applications for the Delivery and Monitoring of Gene Therapy for Central Nervous System Diseases [PDF]

Neurological disease due to single gene defects represents a targetable entity for adeno-associated virus (AAV) mediated gene therapy. The delivery of AAV-mediated gene therapy to the brain is challenging, owing to the presence of the blood-brain barrier.
Vardar, Zeynep, Gray-Edwards, Heather L, Daci, Rrita, Flotte, Terence R, Shazeeb, Mohammed Salman, Cataltepe, Oguz I, Vachha, Behroze   +6 more
core   +1 more source