316. Enhanced Tumor Growth Inhibition of Subcutaneous Neuro-2a Tumors in Immunocompetent Mice by Combinatorial Therapy with Genetically Engineered HSV-1 Expressing MCP-1 and IL-12 [PDF]
, 2002 openalex +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
849. Genetic Heterogeneity in Response to Adenovirus Gene Therapy [PDF]
, 2002 openalex +1 more source
Molecular Oncology, EarlyView.We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin +10 more
wiley +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
996. Hydrodynamics-Mediated Transfection of the Epstein-Barr Virus (EBV)-Based Plasmid (Episomal) Vectors for Genetic Immunization and Gene Therapy [PDF]
, 2002 openalex +1 more source
A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer
Molecular Oncology, EarlyView.Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla +15 more
wiley +1 more source
1223. Intracerebral Grafting of Hematopoietic Stem Cells Genetically Modified by the VSV-G Pseudo-Type Retroviral Vector GCDNsap as a New Gene and Cellular Therapy for Neurological Disorders [PDF]
, 2002 openalex +1 more source