Results 171 to 180 of about 5,467,287 (313)

Prenatal Evaluation of Genetic Abnormalities in Fetuses With Single Umbilical Artery: A Retrospective Cohort Study

Genetics Research
Yuqin Chen, Xiaoqing Wu, Meiying Cai, Linjuan Su, Xiaorui Xie, Hailong Huang, Rongzhao Zhang, Liangpu Xu   +7 more
doaj   +1 more source

Rationally and in silico guided APOBEC3F-directed CBE for enhanced PDAC genetic therapy. [PDF]

Commun Biol
Fang Q, Zhang J, Wang K, Wang Z, Lv Z, Zhang X, Bi C, Zhang X, Yu J, Feng Y, Zhou T, Hao J, Yang C.   +12 more
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Importance of next generation sequencing for detection of novel pharmacogenomic markers in pediatric acute lymphoblastic leukemia

, 2019
Acute lymphoblastic leukemia (ALL) is the most common malignancy of childhood. Therapy causes side effects in 75% of patients and 1-3% of patients have a lethal outcome as a consequence of treatment.
Janić, Dragana, Milosević, Goran, Zukić, Branka, Stanković, Biljana, Gašić, Vladimir, Kotur, Nikola, Pavlović, Sonja, Zukić, Goran, Dokmanović, Lidija   +8 more
core  

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

In utero genetic therapy: Treatment of early onset neurological disorders before they start. [PDF]

Mol Ther
Borges B, Brown SM, MacKenzie TC, Sumner CJ.   +3 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Generation and Treatment of a Novel Severe Model of Visceral Gaucher Disease by Genetic Therapy. [PDF]

Pharmaceutics
Geard AF, Massaro G, Hughes MP, Arbuthnot P, Waddington SN, Rahim AA.   +5 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Topical miRNA Delivery via Elastic Liposomal Formulation: A Promising Genetic Therapy for Cutaneous Lupus Erythematosus (CLE). [PDF]

Int J Mol Sci
Joseph-Mullol B, Royo M, Preat V, Moliné T, Ferrer B, Aparicio G, Cortés-Hernández J, Solé C.   +7 more
europepmc   +1 more source