Results 161 to 170 of about 1,008,568 (216)
Gene therapy for pediatric genetic kidney diseases [PDF]
Pediatric Discovery, 2023 Genetic kidney disease is the main cause of chronic kidney disease in children. While the pathogenic genes associated with most genetic kidney diseases have been identified, the underlying mechanisms of disease initiation remain ambiguous, and effective ...
Lirong Zhang
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Transplantation Proceedings, 2005
Cellular genetic therapy is the ultimate frontier for those pathologies that are consequent to a specific nonfunctional cellular type. A viable cure for there kinds of diseases is the replacement of sick cells with healthy ones, which can be obtained from the same patient or a different donor.
Del Vecchio, F +4 more
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Cellular genetic therapy is the ultimate frontier for those pathologies that are consequent to a specific nonfunctional cellular type. A viable cure for there kinds of diseases is the replacement of sick cells with healthy ones, which can be obtained from the same patient or a different donor.
Del Vecchio, F +4 more
openaire +4 more sources
Genetic therapies and xenotransplantation
Expert Opinion on Biological Therapy, 2002The number of patients in need of an organ transplant is increasing, while the number of satisfactory sources of organs has declined in many countries [101]. The resulting shortage of human organs has spurred an urgent effort to investigate alternative therapies, including the use of animal organs, tissues and cells (i.e., xenotransplantation ...
Brenda M, Ogle, Jeffrey L, Platt
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Genetic therapy for congenital myopathies
Current Opinion in Neurology, 2021Purpose of review There has been an explosion of advancement in the field of genetic therapies. The first gene-based treatments are now in clinical practice, with several additional therapeutic programs in various stages of development.
Nika, Maani +2 more
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Gene Therapy for Genetic Diseases
Cancer Investigation, 1989(1989). Gene Therapy for Genetic Diseases. Cancer Investigation: Vol. 7, No. 2, pp. 179-192.
D B, Kohn, W F, Anderson, R M, Blaese
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Genetic therapies for cardiovascular diseases
Trends in Molecular Medicine, 2005Recent advances in understanding the molecular and cellular basis of cardiovascular diseases, together with the availability of tools for genetic manipulation of the cardiovascular system, offer possibilities for new treatments. Gene therapies have demonstrated potential usefulness for treating complex cardiovascular diseases, such as hypertension ...
Luis G, Melo +3 more
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New England Journal of Medicine, 1987
Inherited disorders have been perceived by the general medical profession as unfortunate accidents of nature that are essentially untreatable.
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Inherited disorders have been perceived by the general medical profession as unfortunate accidents of nature that are essentially untreatable.
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Genetic prodrug activation therapy
The Lancet, 1997Genetic prodrug activation therapy shows promise as a therapeutic option for the treatment of cancer as well as a variety of other diseases. It involves the insertion of a gene encoding a drug-metabolizing enzyme into cells and the systemic administration of a prodrug. The prodrug is converted to a cytotoxic agent by the action of the expressed enzyme.
L A, Martin +4 more
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Expert Opinion on Biological Therapy, 2003
Despite the tremendous success of highly active antiretroviral treatment (HAART) introduced nearly 8 years ago for the treatment of human immunodeficiency virus (HIV), innovative therapies, including gene transfer approaches, are still required for nearly half of the general patient population.
Ananthalakshmi, Poluri +2 more
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Despite the tremendous success of highly active antiretroviral treatment (HAART) introduced nearly 8 years ago for the treatment of human immunodeficiency virus (HIV), innovative therapies, including gene transfer approaches, are still required for nearly half of the general patient population.
Ananthalakshmi, Poluri +2 more
openaire +2 more sources
Genetic therapies and xenotransplantation
Expert Opinion on Investigational Drugs, 1999There is an acute shortage of human organs available for transplantation. Transplanting animal organs or tissues is a potential solution and could also provide a novel means of gene delivery. Xenotransplantation faces many challenges, including the immune response of the recipient against the transplant, the physiological limitations of the transplant ...
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