Results 141 to 150 of about 5,467,287 (313)
Therapeutic future of Fuchs endothelial corneal dystrophy: An ongoing way to explore
Taiwan Journal of OphthalmologyFuchs endothelial corneal dystrophy (FECD) is one of the most common corneal diseases that causes loss of visual acuity in the world. FECD is a genetically and pathogenetically heterogeneous disease that results in the failure of corneal endothelial ...
Jia-Xin Liu +3 more
doaj +1 more source
Genetic and immunological therapy for cancer [PDF]
Journal of the Royal Society of Medicine, 2000 A, Young, D J, Kerr
openaire +2 more sources
Correction of a Genetic Defect by Nuclear Transplantation and Combined Cell and Gene Therapy
, 2002 CORRECTION OF A GENETIC DEFECT BY NUCLEAR TRANSPLANTATION AND COMBINED CELL AND GENE THERAPY Correction of a Genetic Defect by Nuclear Transplantation and Combined Cell and Gene Therapy (109) (-
Rideout III, William M. Konrad Hochedlinger Michael Kyba George Q. Daley Rudolf Jaenisch
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Intellectual disability (ID) is a prevalent neurodevelopmental disorder characterized by neurodevelopmental defects such as the congenital impairment of intellectual function and restricted adaptive behavior.
Kexin Hou, Xinyan Zheng
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
What's in a name? : titles used in diversional therapy
, 2020 After being involved in numerous discussions and debates over decades a question that is constantly asked by people in our field of practice is what title should we use?
Alford, Stewart (R19505) +1 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Text-book of Osteopathy : from the Standpoint of Mechano-Therapy
, 1910 This treatise on Osteopathy presents a few of the essentials of one branch of Mechano-Therapy, the eclectic system of Drugless Healing. For we beg to remind the reader that the application of the principles of Osteopathy alone is just as insufficient ...
American College of Mechano-Therapy
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