Results 121 to 130 of about 9,448,988 (355)

Nanoparticle-mediated mRNA delivery for cancer, autoimmunity, and genetic diseases: a rapid review

Frontiers in Drug Delivery
IntroductionMessenger RNA (mRNA) therapeutics have advanced from experimental platforms to clinical application, driven largely by the success of lipid nanoparticle (LNP)-based COVID-19 vaccines.
Okechukwu Paul-Chima Ugwu, Fabian C. Ogenyi, Mariam Basajja, Chinyere N. Ugwu, Mundu M. Mustafa, Michael Ben Okon   +5 more
doaj   +1 more source

Role of gene therapy in treatment of cancer for craniofacial regeneration—current molecular strategies, future perspectives, and challenges: a narrative review [PDF]

Journal of Yeungnam Medical Science
Gene therapy involves the introduction of foreign genetic material into host tissue to alter the expression of genetic products. Gene therapy represents an opportunity to alter the course of various diseases.
Himanshu Singh
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Clinical Application of Noninvasive Prenatal Testing in Singleton Pregnancy with and without in vitro Fertilization: A 6-year Observational Study at a Single Tertiary Center

International Journal of Women's Health
Qian Zhang,* Yuhong Guo,* Bin Liang, Meihuan Chen, Xiaoqing Wu, Na Lin, Hailong Huang, Liangpu Xu Department of Medical Genetic Diagnosis and Therapy Center, Fujian Key Laboratory for Prenatal Diagnosis and Birth Defect, Fujian Maternity ...
Zhang Q, Guo Y, Liang B, Chen M, Wu X, Lin N, Huang H, Xu L   +7 more
doaj  

Glycogen Storage Disease Type IX in a 6-year-old Male: A Case Report [PDF]

Journal of Pediatrics Review
Background: Glycogen storage diseases (GSDs) are a group of inherited metabolic disorders caused by enzyme deficiencies affecting glycogen synthesis or breakdown. Glycogen, stored mainly in the liver and muscles, is crucial for maintaining glucose levels
Shahab Noorian, Hossein Moravej, Zhila Afshar, Afagh Hassanzadeh Rad, Setila Dalili   +4 more
doaj  

Cell and Gene Therapy: Transforming Treatment Paradigms for Patient‐Centric Care

Clinical and Translational Science
Cell and gene therapies (CGTs) are transforming medicine by offering potential cures for diseases previously considered untreatable. Despite rapid advancements, challenges remain in optimizing efficacy and safety and ensuring patient accessibility and ...
Sojeong Yi, Chia‐Yung Wu, Avery McIntosh, Maria E. Santaella, Tara M. Robinson, Michael Z. Liao   +5 more
doaj   +1 more source

Exploring Embryonic and Postnatal Gene Therapy Approaches for GJB2-Related Deafness: A Scoping Review

Audiology Research
Purpose: Hearing loss (HL) is a prevalent condition significantly impairing quality of life, with genetic mutations accounting for a substantial proportion of congenital cases, notably those involving the GJB2 gene encoding connexin 26.
Valeria Caragli, Alessandro Martini
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The Development of Regulatory Standards for Gene Therapy in the European Union [PDF]

, 1994
This note examines the EU\u27s efforts to regulate gene therapy, considering the Union\u27s resolve to establish scientifically, economically, and morally sound parameters acceptable to its varied constituency.
De Jager, Charles F.
core   +1 more source

Interaction between the MTHFR C677T polymorphism and traumatic childhood events predicts depression [PDF]

, 2013
Childhood trauma is associated with the onset and recurrence of major depressive disorder (MDD). The thermolabile T variant of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism (rs1801133) is associated with a limited (oxidative) stress ...
Assies, J, Bockting, CLH, Boks, M P, Kahn, RS, Koeter, MWJ, Lok, A, Mocking, RJT, Schene, AH, Snieder, H, Vinkers, CH   +9 more
core   +3 more sources