Results 151 to 160 of about 1,003,750 (315)
Gene Therapy: A Paradigm Shift in Dentistry
, 2016 Gene therapy holds a promising future for bridging the gap between the disciplines of medicine and clinical dentistry. The dynamic treatment approaches of gene therapy have been advancing by leaps and bounds.
Nida Siddique +4 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Genetic basis of phage-host interaction: Towards effective phage therapy of non-typhoidal Salmonella
, 2022 Non-typhoidal Salmonella (NTS) have adapted to cause invasive illness in humans. Bacteria have developed MDR against current antibiotics. Bacteriophage therapy is the hope for bacterial treatment however one of the key limitations is the limited host ...
Mohammed, M.
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
GENETIC SPECTRUM OF PRIMARY DYSLIPIDEMIAS IN CHILDREN - SINGLE CENTER EXPERIENCE
Primary dyslipidemias are heterogenous metabolic disorders caused by pathogenic genetic variants. Over 100 genes have been identified that impact lipid metabolism, with familial hypercholesterolemia being the most common form, occurring in the general ...
Sarajlija, Adrijan +8 more
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Intellectual disability (ID) is a prevalent neurodevelopmental disorder characterized by neurodevelopmental defects such as the congenital impairment of intellectual function and restricted adaptive behavior.
Kexin Hou, Xinyan Zheng
core +1 more source
Genetic Mechanisms of Asthma and the Implications for Drug Repositioning
, 2018 Asthma is a chronic disease that is caused by airway inflammation. The main features of asthma are airway hyperresponsiveness (AHR) and reversible airway obstruction. The disease is mainly managed using drug therapy.
Yue Huo, Hong-Yu Zhang
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Just Genetics: How far does the moratorium on the use of genetic data by insurers within the UK accord with Rawls’ principles of justice? [PDF]
, 2013 Since the completion of the Human Genome Project in 2004, understanding of genetic information has expanded, opening much greater possibilities with regard to identifying, diagnosing and treating genetic conditions.
Douglass, Benjamin
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