Results 201 to 210 of about 7,770,494 (359)

Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy.

Cancer Cell, 2014
Jens G. Lohr, P. Stojanov, S. Carter, Peter Cruz-Gordillo, M. Lawrence, D. Auclair, C. Sougnez, B. Knoechel, Joshua Gould, G. Saksena, K. Cibulskis, A. McKenna, M. Chapman, R. Straussman, J. Levy, L. Perkins, J. Keats, S. Schumacher, Mara W Rosenberg, G. Getz, T. Golub   +20 more
semanticscholar   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

857. Genetic Mapping of the Humeral Immune Response to Adenovirus Gene Therapy [PDF]

, 2002

openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease.

Blood, 2016
Megan D Hoban, S. Orkin, D. E. Bauer
semanticscholar   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

Genetic heterogeneity in response to adenovirus gene therapy. [PDF]

, 2003
Pierre Lefesvre, Joline Attema, Angelique A. C. Lemckert, Menzo Havenga, Dirk van Bekkum   +4 more
openalex   +1 more source

Genetic Heterogeneity in Therapy-Naïve Synchronous Primary Breast Cancers and Their Metastases

Clinical Cancer Research, 2017
C. Ng, F. Bidard, S. Piscuoglio, F. Geyer, R. Lim, Ino de Bruijn, R. Shen, F. Pareja, Samuel H. Berman, Lu Wang, J. Pierga, A. Vincent-Salomon, A. Viale, L. Norton, B. Sigal, B. Weigelt, P. Cottu, J. Reis-Filho   +17 more
semanticscholar   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Glutathione S-transferase genotypes, genetic susceptibility, and outcome of therapy in childhood acute lymphoblastic leukemia

, 2002
Stella M. Davies, Ravi Bhatia, Julie A. Ross, William R. Kiffmeyer, Paul S. Gaynon, Gretchen A. Radloff, Leslie L. Robison, John P. Perentesis   +7 more
openalex   +1 more source