Results 311 to 320 of about 1,463,301 (359)
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Transplantation Proceedings, 2005
Cellular genetic therapy is the ultimate frontier for those pathologies that are consequent to a specific nonfunctional cellular type. A viable cure for there kinds of diseases is the replacement of sick cells with healthy ones, which can be obtained from the same patient or a different donor.
Del Vecchio, F +4 more
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Cellular genetic therapy is the ultimate frontier for those pathologies that are consequent to a specific nonfunctional cellular type. A viable cure for there kinds of diseases is the replacement of sick cells with healthy ones, which can be obtained from the same patient or a different donor.
Del Vecchio, F +4 more
openaire +5 more sources
Genetic therapies and xenotransplantation
Expert Opinion on Biological Therapy, 2002The number of patients in need of an organ transplant is increasing, while the number of satisfactory sources of organs has declined in many countries [101]. The resulting shortage of human organs has spurred an urgent effort to investigate alternative therapies, including the use of animal organs, tissues and cells (i.e., xenotransplantation ...
Brenda M. Ogle, Jeffrey L. Platt
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Genetic therapy for congenital myopathies
Current Opinion in Neurology, 2021Purpose of review There has been an explosion of advancement in the field of genetic therapies. The first gene-based treatments are now in clinical practice, with several additional therapeutic programs in various stages of development.
James J. Dowling +2 more
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Expert Opinion on Biological Therapy, 2003
Despite the tremendous success of highly active antiretroviral treatment (HAART) introduced nearly 8 years ago for the treatment of human immunodeficiency virus (HIV), innovative therapies, including gene transfer approaches, are still required for nearly half of the general patient population.
Richard E. Sutton +2 more
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Despite the tremendous success of highly active antiretroviral treatment (HAART) introduced nearly 8 years ago for the treatment of human immunodeficiency virus (HIV), innovative therapies, including gene transfer approaches, are still required for nearly half of the general patient population.
Richard E. Sutton +2 more
openaire +2 more sources
Pediatric Clinics of North America, 1997
The early stages of genetic therapy present challenges for clinicians and basic scientists. Clinicians must become familiar with new terminology and concepts, and must keep a perspective on the new field in the face of inflated claims and high-profile failures. Basic scientists must continually return to disease models and to patients to determine what
Thomas W. Ferkol, Terence R. Flotte
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The early stages of genetic therapy present challenges for clinicians and basic scientists. Clinicians must become familiar with new terminology and concepts, and must keep a perspective on the new field in the face of inflated claims and high-profile failures. Basic scientists must continually return to disease models and to patients to determine what
Thomas W. Ferkol, Terence R. Flotte
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New England Journal of Medicine, 1987
Inherited disorders have been perceived by the general medical profession as unfortunate accidents of nature that are essentially untreatable.
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Inherited disorders have been perceived by the general medical profession as unfortunate accidents of nature that are essentially untreatable.
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Genetic therapies in cystic fibrosis
Current Opinion in Pulmonary Medicine, 2023Purpose of review Advances in cystic fibrosis (CF) therapies over the past decade pivotally changed the morbidity and mortality of CF with the advent of cystic fibrosis transmembrane conductance regulator (CFTR) modulators that rescue dysfunctional CFTR protein in individuals with eligible genotypes.
Jennifer L, Taylor-Cousar +3 more
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Genetic prodrug activation therapy
The Lancet, 1997Genetic prodrug activation therapy shows promise as a therapeutic option for the treatment of cancer as well as a variety of other diseases. It involves the insertion of a gene encoding a drug-metabolizing enzyme into cells and the systemic administration of a prodrug. The prodrug is converted to a cytotoxic agent by the action of the expressed enzyme.
H. S. Pandha +4 more
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Genetic therapies and xenotransplantation
Expert Opinion on Investigational Drugs, 1999There is an acute shortage of human organs available for transplantation. Transplanting animal organs or tissues is a potential solution and could also provide a novel means of gene delivery. Xenotransplantation faces many challenges, including the immune response of the recipient against the transplant, the physiological limitations of the transplant ...
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Gene Therapy for Genetic Diseases
Cancer Investigation, 1989(1989). Gene Therapy for Genetic Diseases. Cancer Investigation: Vol. 7, No. 2, pp. 179-192.
R. Michael Blaese +2 more
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