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Genetic therapies and xenotransplantation
Expert Opinion on Biological Therapy, 2002The number of patients in need of an organ transplant is increasing, while the number of satisfactory sources of organs has declined in many countries [101]. The resulting shortage of human organs has spurred an urgent effort to investigate alternative therapies, including the use of animal organs, tissues and cells (i.e., xenotransplantation ...
Brenda M, Ogle, Jeffrey L, Platt
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Gene Therapy for Genetic Diseases
Cancer Investigation, 1989(1989). Gene Therapy for Genetic Diseases. Cancer Investigation: Vol. 7, No. 2, pp. 179-192.
D B, Kohn, W F, Anderson, R M, Blaese
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New England Journal of Medicine, 1987
Inherited disorders have been perceived by the general medical profession as unfortunate accidents of nature that are essentially untreatable.
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Inherited disorders have been perceived by the general medical profession as unfortunate accidents of nature that are essentially untreatable.
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Genetic therapies for cardiovascular diseases
Trends in Molecular Medicine, 2005Recent advances in understanding the molecular and cellular basis of cardiovascular diseases, together with the availability of tools for genetic manipulation of the cardiovascular system, offer possibilities for new treatments. Gene therapies have demonstrated potential usefulness for treating complex cardiovascular diseases, such as hypertension ...
Luis G, Melo +3 more
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Expert Opinion on Biological Therapy, 2003
Despite the tremendous success of highly active antiretroviral treatment (HAART) introduced nearly 8 years ago for the treatment of human immunodeficiency virus (HIV), innovative therapies, including gene transfer approaches, are still required for nearly half of the general patient population.
Ananthalakshmi, Poluri +2 more
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Despite the tremendous success of highly active antiretroviral treatment (HAART) introduced nearly 8 years ago for the treatment of human immunodeficiency virus (HIV), innovative therapies, including gene transfer approaches, are still required for nearly half of the general patient population.
Ananthalakshmi, Poluri +2 more
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Genetic therapies and xenotransplantation
Expert Opinion on Investigational Drugs, 1999There is an acute shortage of human organs available for transplantation. Transplanting animal organs or tissues is a potential solution and could also provide a novel means of gene delivery. Xenotransplantation faces many challenges, including the immune response of the recipient against the transplant, the physiological limitations of the transplant ...
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A New Era for Rare Genetic Diseases: Messenger RNA Therapy
Human Gene Therapy, 2019Exogenous delivery of messenger RNA (mRNA) is emerging as a new class of medicine with broad applicability including the potential to treat rare monogenic disorders.
P. Martini, L. Guey
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Seminars in interventional cardiology : SIIC, 1998
Vascular gene transfer is the introduction of foreign DNA into host cells within the vessel wall. Expression of recombinant genes within vascular cells has been demonstrated in normal, injured and atherosclerotic arteries. Transfer of genes with biological activity has provided insights into the role of specific genes in normal and pathological states.
R D, Simari, E G, Nabel
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Vascular gene transfer is the introduction of foreign DNA into host cells within the vessel wall. Expression of recombinant genes within vascular cells has been demonstrated in normal, injured and atherosclerotic arteries. Transfer of genes with biological activity has provided insights into the role of specific genes in normal and pathological states.
R D, Simari, E G, Nabel
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Genetic therapies to lower cholesterol
Vascular Pharmacology, 2015This review surveys the state-of-the-art in genetic therapies for familial hypercholesterolaemia (FH), caused most commonly by mutations in the LDL receptor (LDLR) gene. FH manifests as highly elevated low density lipoprotein (LDL) cholesterol levels and consequently accelerated atherosclerosis.
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Renal cancer: Genetic directed therapy
Urologic Oncology: Seminars and Original Investigations, 2009Until recently, the distinction made between various renal cancers was based on histology alone. However, we have clearly entered the era of molecular genetics. The Human Genome Project is arguably the most important scientific achievement of the last half century [1].
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