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Genetic therapies for cardiovascular diseases
Trends in Molecular Medicine, 2005Recent advances in understanding the molecular and cellular basis of cardiovascular diseases, together with the availability of tools for genetic manipulation of the cardiovascular system, offer possibilities for new treatments. Gene therapies have demonstrated potential usefulness for treating complex cardiovascular diseases, such as hypertension ...
Luis G. Melo +4 more
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New England Journal of Medicine, 1974
Present efforts at therapy in the major groups of genetic diseases have met with varying degrees of success. In the common multifactorial disorders, in which the genetic predisposition frequently depends heavily on precipitating environmental factors for its expression, treatment is often effective, as in the therapy of diabetes mellitus with insulin ...
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Present efforts at therapy in the major groups of genetic diseases have met with varying degrees of success. In the common multifactorial disorders, in which the genetic predisposition frequently depends heavily on precipitating environmental factors for its expression, treatment is often effective, as in the therapy of diabetes mellitus with insulin ...
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Genetics of Response to Antiplatelet Therapy
2014Dual antiplatelet therapy has a major role in the management of acute coronary syndromes (ACS) and following percutaneous coronary intervention (PCI). However, significant variation in pharmacodynamic response to antiplatelet therapy has been demonstrated, especially to clopidogrel.
Robert F. Storey, Mark R Thomas
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Gene therapy for genetic diseases
Pediatrics International, 1998Abstract Gene therapy provides the potential to permanently cure selected genetic diseases. However, a major obstacle is the effective delivery of the normal gene to specific target sites of pathology and continuous expression at therapeutic levels. A variety of viral and non‐viral vectors have been developed to deliver genes to various cells, tissues ...
Edward H. Schuchman, Robert J. Desnick
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Genetic therapies to lower cholesterol
Vascular Pharmacology, 2015This review surveys the state-of-the-art in genetic therapies for familial hypercholesterolaemia (FH), caused most commonly by mutations in the LDL receptor (LDLR) gene. FH manifests as highly elevated low density lipoprotein (LDL) cholesterol levels and consequently accelerated atherosclerosis.
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Ethical Issues in Genetic Therapy
Journal of Obstetric, Gynecologic & Neonatal Nursing, 1994Ethical issues in genetic therapy involve the use of genetic science for human good and the avoidance of preventable harms. Immediate issues are the control and confidentiality of results of genetic testing, possible discrimination against those found to have genetic diseases, and the just allocation of beneficial genetic therapies. Less practical, but
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Gene Therapy for Genetic Diseases
Human Gene Therapy, 1994(1989). Gene Therapy for Genetic Diseases. Cancer Investigation: Vol. 7, No. 2, pp. 179-192.
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2017
Contents: Series preface Introduction. Genetics a " General:Human genetics: the new panacea?, Julian Kinderlerer and Diane Longley Regulation as facilitation: negotiating the genetic revolution, Julia Black Whose genome project?, Darryl Macer The gene genie: good fairy or wicked witch?, Sheila A.M.
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Contents: Series preface Introduction. Genetics a " General:Human genetics: the new panacea?, Julian Kinderlerer and Diane Longley Regulation as facilitation: negotiating the genetic revolution, Julia Black Whose genome project?, Darryl Macer The gene genie: good fairy or wicked witch?, Sheila A.M.
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GENETIC AND CELLULAR THERAPIES FOR CEREBRAL INFARCTION
Neurosurgery, 2004Neurosurgeons, working as surgical scientists, can have a prominent role in developing and implementing genetic and cellular therapies for cerebral ischemia. The rapid emergence of both genetic and cellular therapies for neural regeneration warrants a careful analysis before implementation of human studies to understand the pitfalls and promises of ...
Bob S. Carter, Oszkar Szentirmai
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Genetically Informed Therapy in Leukemia
New England Journal of Medicine, 2013What can we learn from the study of rare diseases? A lot. Chronic myeloid leukemia (CML) occurs in 3 in 100,000 persons, yet it is perhaps the best example of “bench to bedside” medicine in oncology. The discovery of the signature BCR-ABL translocation found in all CML ushered in an era of molecular diagnostics and targeted therapy with tyrosine kinase
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