Results 341 to 350 of about 8,605,496 (403)
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New England Journal of Medicine, 1987
Inherited disorders have been perceived by the general medical profession as unfortunate accidents of nature that are essentially untreatable.
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Inherited disorders have been perceived by the general medical profession as unfortunate accidents of nature that are essentially untreatable.
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Genetic therapies for cardiovascular diseases
Trends in Molecular Medicine, 2005Recent advances in understanding the molecular and cellular basis of cardiovascular diseases, together with the availability of tools for genetic manipulation of the cardiovascular system, offer possibilities for new treatments. Gene therapies have demonstrated potential usefulness for treating complex cardiovascular diseases, such as hypertension ...
Luis G, Melo +3 more
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Expert Opinion on Biological Therapy, 2003
Despite the tremendous success of highly active antiretroviral treatment (HAART) introduced nearly 8 years ago for the treatment of human immunodeficiency virus (HIV), innovative therapies, including gene transfer approaches, are still required for nearly half of the general patient population.
Ananthalakshmi, Poluri +2 more
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Despite the tremendous success of highly active antiretroviral treatment (HAART) introduced nearly 8 years ago for the treatment of human immunodeficiency virus (HIV), innovative therapies, including gene transfer approaches, are still required for nearly half of the general patient population.
Ananthalakshmi, Poluri +2 more
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Genetic therapies and xenotransplantation
Expert Opinion on Investigational Drugs, 1999There is an acute shortage of human organs available for transplantation. Transplanting animal organs or tissues is a potential solution and could also provide a novel means of gene delivery. Xenotransplantation faces many challenges, including the immune response of the recipient against the transplant, the physiological limitations of the transplant ...
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Genetic therapies to lower cholesterol
Vascular Pharmacology, 2015This review surveys the state-of-the-art in genetic therapies for familial hypercholesterolaemia (FH), caused most commonly by mutations in the LDL receptor (LDLR) gene. FH manifests as highly elevated low density lipoprotein (LDL) cholesterol levels and consequently accelerated atherosclerosis.
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A New Era for Rare Genetic Diseases: Messenger RNA Therapy
Human Gene Therapy, 2019Exogenous delivery of messenger RNA (mRNA) is emerging as a new class of medicine with broad applicability including the potential to treat rare monogenic disorders.
P. Martini, L. Guey
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Genetics of Response to Antiplatelet Therapy
2014Dual antiplatelet therapy has a major role in the management of acute coronary syndromes (ACS) and following percutaneous coronary intervention (PCI). However, significant variation in pharmacodynamic response to antiplatelet therapy has been demonstrated, especially to clopidogrel.
Mark R, Thomas, Robert F, Storey
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Seminars in interventional cardiology : SIIC, 1998
Vascular gene transfer is the introduction of foreign DNA into host cells within the vessel wall. Expression of recombinant genes within vascular cells has been demonstrated in normal, injured and atherosclerotic arteries. Transfer of genes with biological activity has provided insights into the role of specific genes in normal and pathological states.
R D, Simari, E G, Nabel
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Vascular gene transfer is the introduction of foreign DNA into host cells within the vessel wall. Expression of recombinant genes within vascular cells has been demonstrated in normal, injured and atherosclerotic arteries. Transfer of genes with biological activity has provided insights into the role of specific genes in normal and pathological states.
R D, Simari, E G, Nabel
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Gene therapy for genetic diseases
Pediatrics International, 1998Abstract Gene therapy provides the potential to permanently cure selected genetic diseases. However, a major obstacle is the effective delivery of the normal gene to specific target sites of pathology and continuous expression at therapeutic levels. A variety of viral and non‐viral vectors have been developed to deliver genes to various cells, tissues ...
R J, Desnick, E H, Schuchman
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Ethical Issues in Genetic Therapy
Journal of Obstetric, Gynecologic & Neonatal Nursing, 1994Ethical issues in genetic therapy involve the use of genetic science for human good and the avoidance of preventable harms. Immediate issues are the control and confidentiality of results of genetic testing, possible discrimination against those found to have genetic diseases, and the just allocation of beneficial genetic therapies. Less practical, but
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