Results 31 to 40 of about 7,531,202 (384)

The possibility of blocking the process of DNA base pairs opening by hydrogen peroxide [PDF]

Ukr. J. Phys, 64(6), 500-508 (2019), 2019
One of the most progressive methods of cancer treatment is ion beam therapy. The simulations of water radiolysis show that in the cell medium the most long-living species are hydrogen peroxide (H$_2$O$_2$) molecules. But up to the present time the role of H$_2$O$_2$ molecules in the deactivation of cancer cells has not been determined yet.
arxiv   +1 more source

The seroprevalence of neutralizing antibodies against the adeno-associated virus capsids in Japanese hemophiliacs

Molecular Therapy: Methods & Clinical Development, 2022
Adeno-associated virus (AAV) vectors are promising modalities of gene therapy to address unmet medical needs. However, anti-AAV neutralizing antibodies (NAbs) hamper the vector-mediated therapeutic effect.
Yuji Kashiwakura, Nemekhbayar Baatartsogt, Shoji Yamazaki, Azusa Nagao, Kagehiro Amano, Nobuaki Suzuki, Tadashi Matsushita, Akihiro Sawada, Satoshi Higasa, Naoya Yamasaki, Teruhisa Fujii, Taemi Ogura, Hideyuki Takedani, Masashi Taki, Takeshi Matsumoto, Jun Yamanouchi, Michio Sakai, Masako Nishikawa, Yutaka Yatomi, Koji Yada, Keiji Nogami, Ryota Watano, Takafumi Hiramoto, Morisada Hayakawa, Nobuhiko Kamoshita, Akihiro Kume, Hiroaki Mizukami, Shizukiyo Ishikawa, Yoichi Sakata, Tsukasa Ohmori   +29 more
doaj  

Genetic therapies against HIV [PDF]

Nature Biotechnology, 2007
Highly active antiretroviral therapy prolongs the life of HIV-infected individuals, but it requires lifelong treatment and results in cumulative toxicities and viral-escape mutants. Gene therapy offers the promise of preventing progressive HIV infection by sustained interference with viral replication in the absence of chronic chemotherapy.
Donald B. Kohn, John J. Rossi, Carl H. June   +2 more
openaire   +3 more sources

Design of an optimal combination therapy with broadly neutralizing antibodies to suppress HIV-1 [PDF]

arXiv, 2021
Broadly neutralizing antibodies (bNAbs) are promising targets for vaccination and therapy against HIV. Passive infusions of bNAbs have shown promise in clinical trials as a potential alternative for anti-retroviral therapy. A key challenge for the potential clinical application of bnAbs is the suppression of viral escape, which is more effectively ...
arxiv  

A graph neural network-based model with Out-of-Distribution Robustness for enhancing Antiretroviral Therapy Outcome Prediction for HIV-1 [PDF]

, 2023
Predicting the outcome of antiretroviral therapies (ART) for HIV-1 is a pressing clinical challenge, especially when the ART includes drugs with limited effectiveness data. This scarcity of data can arise either due to the introduction of a new drug to the market or due to limited use in clinical settings, resulting in clinical dataset with highly ...
arxiv   +1 more source

Development and Clinical Translation of Approved Gene Therapy Products for Genetic Disorders

Frontiers in Genetics, 2019
The field of gene therapy is striving more than ever to define a path to the clinic and the market. Twenty gene therapy products have already been approved and over two thousand human gene therapy clinical trials have been reported worldwide.
Alireza Shahryari, Marie saghaeian Jazi, S. Mohammadi, Hadi Razavi Nikoo, Zahra Nazari, Elaheh Sadat Hosseini, I. Burtscher, S. Mowla, H. Lickert   +8 more
semanticscholar   +1 more source

Genetic Variants Associated With Cancer Therapy–Induced Cardiomyopathy

Circulation, 2019
Supplemental Digital Content is available in the text.
P. García-Pavía, Yuri Kim, M. A. Restrepo-Córdoba, I. Lunde, H. Wakimoto, A. Smith, Christopher N Toepfer, K. Getz, J. Gorham, Parth N. Patel, Kaoru Ito, J. A. Willcox, Z. Arany, Jian Li, A. Owens, R. Govind, B. Nuñez, Erica Mazaika, A. Bayés‐Genís, R. Walsh, B. Finkelman, J. Lupón, N. Whiffin, I. Serrano, W. Midwinter, Alicja E Wilk, A. Bardají, N. Ingold, R. Buchan, U. Tayal, D. Pascual-Figal, A. de Marvao, Mian Ahmad, J. M. García-Pinilla, A. Pantazis, F. Domínguez, A. John Baksi, D. O’Regan, S. Rosen, S. Prasad, E. Lara-Pezzi, M. Provencio, A. Lyon, L. Alonso-Pulpón, S. Cook, S. DePalma, P. Barton, R. Aplenc, J. Seidman, B. Ky, J. Ware, C. Seidman   +51 more
semanticscholar   +1 more source

Genetics and therapy for pediatric eye diseases [PDF]

EBioMedicine, 2021
Ocular morphogenesis in vertebrates is a highly organized process, orchestrated largely by intrinsic genetic programs that exhibit stringent spatiotemporal control. Alternations in these genetic instructions can lead to hereditary or nonhereditary congenital disorders, a major cause of childhood visual impairment, and contribute to common late-onset ...
Holly.Y. Chen, Ordan J. Lehmann, Anand Swaroop   +2 more
openaire   +4 more sources

Prenatal diagnosis and genetic etiology analysis of talipes equinovarus by chromosomal microarray analysis

BMC Medical Genomics, 2023
Background With the advancement of molecular technology, fetal talipes equinovarus (TE) is believed to be not only associated with chromosome aneuploidy, but also related to chromosomal microdeletion and microduplication.
Xiaorui Xie, Baojia Huang, Linjuan Su, Meiying Cai, Yuqin Chen, Xiaoqing Wu, Liangpu Xu   +6 more
doaj   +1 more source

Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders

Nature Communications, 2019
Fifty percent of inner ear disorders are caused by genetic mutations. To develop treatments for genetic inner ear disorders, we designed gene replacement therapies using synthetic adeno-associated viral vectors to deliver the coding sequence for ...
Carl Nist-Lund, B. Pan, A. Patterson, Y. Asai, Tianwen Chen, Wu Zhou, Hong Zhu, Sandra Romero, Jennifer Resnik, D. Polley, G. Géléoc, J. R. Holt   +11 more
semanticscholar   +1 more source