Results 31 to 40 of about 1,504,225 (383)
Factors modifying the risk for developing acute skin toxicity after whole-breast intensity modulated radiotherapy [PDF]
, 2014 Background: After breast-conserving radiation therapy most patients experience acute skin toxicity to some degree. This may impair patients' quality of life, cause pain and discomfort. In this study, we investigated treatment and patient-related factors,
De Langhe, Sofie +9 more
core +2 more sources
The possibility of blocking the process of DNA base pairs opening by hydrogen peroxide [PDF]
Ukr. J. Phys, 64(6), 500-508 (2019), 2019 One of the most progressive methods of cancer treatment is ion beam therapy. The simulations of water radiolysis show that in the cell medium the most long-living species are hydrogen peroxide (H$_2$O$_2$) molecules. But up to the present time the role of H$_2$O$_2$ molecules in the deactivation of cancer cells has not been determined yet.
arxiv +1 more source
Design of an optimal combination therapy with broadly neutralizing antibodies to suppress HIV-1 [PDF]
arXiv, 2021 Broadly neutralizing antibodies (bNAbs) are promising targets for vaccination and therapy against HIV. Passive infusions of bNAbs have shown promise in clinical trials as a potential alternative for anti-retroviral therapy. A key challenge for the potential clinical application of bnAbs is the suppression of viral escape, which is more effectively ...
arxiv
A graph neural network-based model with Out-of-Distribution Robustness for enhancing Antiretroviral Therapy Outcome Prediction for HIV-1 [PDF]
, 2023 Predicting the outcome of antiretroviral therapies (ART) for HIV-1 is a pressing clinical challenge, especially when the ART includes drugs with limited effectiveness data. This scarcity of data can arise either due to the introduction of a new drug to the market or due to limited use in clinical settings, resulting in clinical dataset with highly ...
arxiv +1 more source
Genetic therapies against HIV [PDF]
Nature Biotechnology, 2007 Highly active antiretroviral therapy prolongs the life of HIV-infected individuals, but it requires lifelong treatment and results in cumulative toxicities and viral-escape mutants. Gene therapy offers the promise of preventing progressive HIV infection by sustained interference with viral replication in the absence of chronic chemotherapy.
Donald B. Kohn +2 more
openaire +3 more sources
Genetics and therapy for pediatric eye diseases [PDF]
EBioMedicine, 2021 Ocular morphogenesis in vertebrates is a highly organized process, orchestrated largely by intrinsic genetic programs that exhibit stringent spatiotemporal control. Alternations in these genetic instructions can lead to hereditary or nonhereditary congenital disorders, a major cause of childhood visual impairment, and contribute to common late-onset ...
Holly.Y. Chen +2 more
openaire +4 more sources
Molecular Therapy: Methods & Clinical Development, 2021 Adeno-associated virus (AAV) vectors are considered efficient vectors for gene transfer, as illustrated by recent successful clinical trials targeting retinal or neurodegenerative disorders.
Gwladys Gernoux +12 more
doaj
Advances in cell transplantation therapy and gene therapy in Parkinson's disease
Chinese Journal of Contemporary Neurology and Neurosurgery, 2022 The role of cell transplantation therapy and gene therapy in the treatment of Parkinson's disease (PD) has attracted more and more attention. It has developed from laboratory research tools to clinical products for patients.
XU Bao⁃lei, CHAN Piu
doaj +1 more source
Tailoring therapy for heart failure: the pharmacogenomics of adrenergic receptor signaling. [PDF]
, 2014 Heart failure is one of the leading causes of mortality in Western countries, and β-blockers are a cornerstone of its treatment. However, the response to these drugs is variable among individuals, which might be explained, at least in part, by genetic ...
Barrese, V +3 more
core +2 more sources
Graft Materials and Biologics for Spinal Interbody Fusion
Biomedicines, 2019 Spinal fusion is the most widely performed procedure in spine surgery. It is the preferred treatment for a wide variety of pathologies including degenerative disc disease, spondylolisthesis, segmental instability, and deformity.
Marissa D’Souza +5 more
doaj +1 more source