Results 171 to 180 of about 752,866 (297)

Editorial: Biochemical and genetic tools to investigate the underlying mechanisms and treatment of sensorimotor pathologies. [PDF]

Front Mol Neurosci, 2022
Hutson TH, Hervera A.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Knockout, Knockdown, and the Schrödinger Paradox: Genetic Immunity to Phenotypic Recapitulation in Zebrafish

Previous research has highlighted significant phenotypic discrepancies between knockout and knockdown approaches in zebrafish, raising concerns about the reliability of these methods.
Álvaro J. Arana, Laura Sánchez
core   +1 more source

Editorial: Advances in genomic and genetic tools, and their applications for understanding embryonic development and human diseases. [PDF]

Front Cell Dev Biol, 2022
Abu-Elmagd M, Assidi M, Alrefaei AF, Rebai A.   +3 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Genetic Tools for Sustainable Management and Conservation of Forest Genetic Resources: Opportunities and Challenges

The management of forest trees has long been a critical challenge in the field of forestry, as these essential natural resources face numerous threats, from climate change and pests to deforestation and unsustainable harvesting practices. Maintaining the
Ramesh, Satpathi, Siddarth
core   +1 more source

Uncovering Insights Into the Biology of Mycobacterium tuberculosis Using Genetic Tools. [PDF]

Microbiologyopen
Stamilla A, Recchia D, Stelitano G, Maci L, Marturano MC, De Rossi E, Chiarelli LR, Pasca MR, Degiacomi G.   +8 more
europepmc   +1 more source

Genetic tools for the stable overexpression of circular RNAs. [PDF]

RNA Biol, 2022
Mecozzi N, Nenci A, Vera O, Bok I, Falzone A, DeNicola GM, Karreth FA.   +6 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The Application of ANN and ANFIS Prediction Models for Thermal Error Compensation on CNC Machine Tools

Thermal errors can have significant effects on Computer Numerical Control (CNC) machine tool accuracy. The errors come from thermal deformations of the machine elements caused by heat sources within the machine structure or from ambient temperature ...
Abdulshahed, Ali
core