Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Combining Genetic Tools to Determine Lipoprotein(a) Concentrations and Their Associated Cardiovascular Risks Across Different Ethnicities. [PDF]
JACC Basic Transl SciSantos RD.
europepmc +1 more source
Fluorescent Genetic Tools for Studying Brown Fat Development and Function in Mice. [PDF]
Methods Mol Biol, 2022 Mukherjee R, Sanchez-Gurmaches J.
europepmc +1 more source
Development of the first marmoset-specific DNA microarray (EUMAMA): a new genetic tool for large-scale expression profiling in a non-human primate [PDF]
, 2007 Nicole A. Datson +11 more
openalex +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Behaviour characteristics estimation tool of genetic distance between sheep breeds
, 2015 Eko Handiwirawan +3 more
openalex +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Editorial: Enhancing livestock breeding through advanced genetic tools and phenotyping systems. [PDF]
Front GenetBai Y.
europepmc +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
The revolution in pharmacotherapy: from herbs to pills, moulds, antibodies to genetic tools. [PDF]
Eur Heart J Cardiovasc PharmacotherLüscher TF.
europepmc +1 more source