Results 111 to 120 of about 1,035,101 (349)

An ordinary differential equation model for the multistep transformation to cancer

, 2004
Cancer is viewed as a multistep process whereby a normal cell is transformed into a cancer cell through the acquisition of mutations. We reduce the complexities of cancer progression to a simple set of underlying rules that govern the transformation of ...
Arends, Armitage, Cahill, DePinho, Folkman, Friberg, Futreal, Hanahan, Jackson, Knudson, Koscielny, Loeb, Luebeck, Nowell, Rajagopalan, Renan, Rew, Sieber, Speer, Tomlinson, Tomlinson, Tomlinson, Vogelstein   +22 more
core   +1 more source

Genetic Transformation in Proteus mirabilis [PDF]

Journal of General Microbiology, 1971
SUMMARY: A method is described for the isolation of biologically active DNA from Proteus mirabilis strain 13 which could transform auxotrophic mutants of P. mirabilis to prototrophy. This DNA preparation did not transform similar mutants of P. vulgaris.
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Ensifer-mediated transformation: an efficient non-Agrobacterium protocol for the genetic modification of rice [PDF]

, 2015
Evelyn Zuniga‐Soto, Ewen Mullins, Beata Dedičová   +2 more
openalex   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A Defined Agar Medium for Genetic Transformation of \u3cem\u3eNeisseria meningitidis\u3c/em\u3e [PDF]

, 1962
Catlin, B. Wesley (Marquette University, Milwaukee, Wis.) and Gertrude M. Schloer. A defined agar medium for genetic transformation of Neisseria meningitidis. J. Bacteriol. 83:470–474.
Catlin, B. Wesley, Schloer, Gertrude M.
core   +1 more source

Supplemental Figure S1 from Whole Exome Sequencing Reveals the Order of Genetic Changes during Malignant Transformation and Metastasis in a Single Patient with NF1-plexiform Neurofibroma

, 2023
Angela C. Hirbe, Sonika Dahiya, Christopher A. Miller, Tiandao Li, Robert S. Fulton, Xiaochun Zhang, Sandra McDonald, Katherine DeSchryver, Eric J. Duncavage, Jessica Walrath, Karlyne M. Reilly, Haley Abel, Melike Pekmezci, Arie Perry, Timothy J. Ley, David H. Gutmann   +15 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Genetic Profiling Uncovers Genome-Wide Loss of Heterozygosity and Provides Insight into Mechanisms of Sarcomatoid Transformation in Chromophobe Renal Cell Carcinoma [PDF]

, 2023
Katrina Collins, Andrés Acosta, Stephanie Siegmund, Liang Cheng, Michelle S. Hirsch, Muhammad T. Idrees   +5 more
openalex   +1 more source