Results 91 to 100 of about 1,035,101 (349)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
RUDN Journal of Agronomy and Animal Industries, 2019 Male gonad cells are considered as promising target cells for the introduction of recombinant DNA within obtaining genetically modified individuals with given characteristics.
Natalya Alexandrovna Volkova +3 more
doaj +1 more source
Near-optimal loop tiling by means of cache miss equations and genetic algorithms [PDF]
, 2002 The effectiveness of the memory hierarchy is critical for the performance of current processors. The performance of the memory hierarchy can be improved by means of program transformations such as loop tiling, which is a code transformation targeted to ...
Abella Ferrer, Jaume +3 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Research progress of nanomaterials in plant genetic transformation
上海师范大学学报. 自然科学版Plant genetic transformation is crucial for improving quality of crop straits, cultivating new varieties with high yield, improved quality, and multi-resistance, thereby reducing the use of pesticides and fertilizers.
YANG Demin +3 more
doaj +1 more source
An economic assessment of banana genetic improvement and innovation in the Lake Victoria Region of Uganda and Tanzania: [PDF]
"This research report highlights findings from a set of studies undertaken by applied economists on the impact of improved banana cultivars and recommended management practices in the East African highlands.
Smale, Melinda +1 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Review and Validation of Plant Gene Function Research Methods Bypassing Tissue Culture
AgronomyThe genetic transformation of plants has provided fundamental insights into plant biology. However, the genetic transformation systems for most horticultural plants remain incomplete.
Huanghuang Jiang +9 more
doaj +1 more source