Results 141 to 150 of about 1,004,687 (332)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Establishment and Application of PEG-Mediated Protoplast Genetic Transformation System of Cordyceps guangdongensis

open access: yesGuangdong nongye kexue
【Objective】Cordyceps guangdongensis, a rare edible-medicinal fungus in China, has been approved as a new resource food, with a broad prospect of industrial application.
Chenghua ZHANG   +7 more
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Agrobacterium-mediated transformation of Citrus sinensis and Citrus limonia epicotyl segments

open access: yesScientia Agricola, 2003
Genetic transformation allows the release of improved cultivars with desirable characteristics in a shorter period of time and therefore may be useful in citrus breeding programs.
Weliton Antonio Bastos de Almeida   +4 more
doaj  

Evidence of genetic transformation in Streptococcus faecium var. durans (SF-O) [PDF]

open access: bronze, 1967
B. M. Mehta   +2 more
openalex   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Tapping into the Potential of Underutilized Niger (Guizotia abyssinica (L. f.) Cass.) Through Breeding and Biotechnological Tools

open access: yesAgriculture
Niger (Guizotia abyssinica (L. f.) Cass.), an oilseed crop from the Compositae family, thrives in temperate and tropical climates. Its small seeds, rich in oil (50–60% biocrude), are widely used for biodiesel, soap production, and as a condiment in ...
Jayashri Narayan Papade   +5 more
doaj   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

open access: yesMolecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh   +8 more
wiley   +1 more source

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