Results 191 to 200 of about 1,004,687 (332)

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Somatic Embryogenesis and Genetic Transformation of <i>Caragana intermedia</i>. [PDF]

Plants (Basel)
Tian J, Zhu J, Deng X, Zhu X, Wang R, Li G.   +5 more
europepmc   +1 more source

Further Observations on Genetic Transformation in Pseudomonas

, 1974
N. C. Khan, S. P. Sen
openalex   +1 more source

Genetic transformation in plants [PDF]

, 1989
R. Walden
openalex   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Genetic Transformation of the Marine Oleaginous Microalga, Marinichlorella sp. NKG400014. [PDF]

Mar Biotechnol (NY)
Kumakubo R, Sagawa K, Tanaka T.
europepmc   +1 more source

Optimization of <i>Agrobacterium tumefaciens</i> mediated genetic transformation protocol for aromatic ric

, 1970
Mohammad Rashed Hossain, Lutful Hassan, AK Patwary, Mostari Jahan Ferdous   +3 more
openalex   +2 more sources

Genetic transformation of genes for protein II in Neisseria gonorrhoeae [PDF]

, 1986
Ruth A. Schwalbe, Janne G. Cannon
openalex   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Direct genetic transformation bypasses tumor-associated DNA methylation alterations. [PDF]

Genome Biol
Hetzel S, Hodis E, Torlai Triglia E, Kovacsovics A, Steinmann K, Gnirke A, Cui M, McQuaid D, Weigert R, Pohl G, Muzumdar MD, Leyvraz S, Keilholz U, Yaspo ML, Regev A, Kretzmer H, Smith ZD, Meissner A.   +17 more
europepmc   +1 more source