Results 191 to 200 of about 546,143 (293)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Establishment of a Genetic Transformation and Gene Editing Method by Floral Dipping in Descurainia sophia. [PDF]

Plants (Basel)
Jia T, Yang H, Zhou D, Zhao S, Wang J, Zhang T, Huang M, Kong D, Liu Y.   +8 more
europepmc   +1 more source

MIF as an oncogenic driver of low‐heterogeneity melanomas

Molecular Oncology, EarlyView.
Shvefel and colleagues identified tumor‐secreted macrophage migration inhibitory factor (MIF) as an upregulated cytokine that mediates immune resistance in melanomas with low‐intratumoral heterogeneity. MIF and its functional paralogue D‐dopachrome tautomerase (D‐DT or MIF‐2) have overlapping but nonidentical signaling functions and are hypothesized to
Thuy T. Tran, Gabriela Athziri Sánchez‐Zuno, Rajan P. Kulkarni, Harriet M. Kluger, Richard Bucala   +4 more
wiley   +1 more source

An Anthocyanin-Based Visual Reporter System for Genetic Transformation and Genome Editing in Cassava. [PDF]

Int J Mol Sci
Zhen XH, Pan RR, Lu XH, Ge YJ, Li RM, Liu J, Wang YJ, Yi KX, Li CX, Guo JC, Yao Y, Geng MT.   +11 more
europepmc   +1 more source

An effective method for establishing a regeneration and genetic transformation system for Actinidia arguta. [PDF]

Front Plant Sci, 2023
Yao W, Kong L, Lei D, Zhao B, Tang H, Zhou X, Lin Y, Zhang Y, Wang Y, He W, Li M, Chen Q, Luo Y, Wang X, Tang H, Zhang Y.   +15 more
europepmc   +1 more source

Neisseria lactamica and Neisseria polysaccharea as possible sources of meningococcal beta-lactam resistance by genetic transformation [PDF]

, 1990
Juan Antonio Sáez-Nieto, Ricardo García Luján, Joaquín V. Martínez‐Suárez, S. Berrón, Julio A. Vázquez, Miguel Viñas, José Campos   +6 more
openalex   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Genetic transformation of GmFBX322 gene and salt tolerance physiology in soybean. [PDF]

PLoS One
He H, Zhang Y, Xu S, Zhang X, Yang X, Cheng Y.   +5 more
europepmc   +1 more source

Cellular mechanism involved with the uptake of DNA molecules during genetic transformation. Review of nine years of studies, 1966--1975. [Bacteria and bacteriophages]

, 1975
Alexander Tomasz
openalex   +2 more sources

175 GENETIC TRANSFORMATION OF COFFEE (COFFEA ARABICA L.) BY AGROBACTERIUM SPP. [PDF]

, 1994
A. Virginia Freire, David A. Lightfoot, John E. Preece   +2 more
openalex   +1 more source