Results 211 to 220 of about 1,032,830 (329)

Direct genetic transformation bypasses tumor-associated DNA methylation alterations. [PDF]

Genome Biol
Hetzel S, Hodis E, Torlai Triglia E, Kovacsovics A, Steinmann K, Gnirke A, Cui M, McQuaid D, Weigert R, Pohl G, Muzumdar MD, Leyvraz S, Keilholz U, Yaspo ML, Regev A, Kretzmer H, Smith ZD, Meissner A.   +17 more
europepmc   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

In Vitro Culture, Genetic Transformation and the Production of Biopharmaceuticals in Microalgae. [PDF]

Int J Mol Sci
Gerszberg A, Kolek L, Hnatuszko-Konka K.
europepmc   +1 more source

A study of in vitro propagation and genetic transformation on dwarf genotypes in cogongrass (Imperata cylindrica) and napiergrass (Pennisetum purpureum Schumach)

, 2013
Nafiatul Umami
openalex   +1 more source

An Overview of Genetic Transformation of Soybean

, 2013
Hye‐Young Lee, So‐Yon Park, J. Zhanyuan   +2 more
openalex   +2 more sources

Developments in RNA interference and genetic transformation to define gene function in parasitic helminths [PDF]

, 2012
David P. Knox
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Estimation of genetic variation in the interval from calving to postpartum ovulation of dairy cows [PDF]

, 1997
Darwash, A.O., Lamming, G.E., Woolliams, John   +2 more
core   +1 more source

Study on Genetic Transformation System of Cabbage (<i>Brassica oleracea</i> var. <i>capitata</i>) Based on Transgenic Root Regeneration. [PDF]

Plants (Basel)
Tao M, Wang W, Shan X, Dai Z, Zhang C, Zhang Z.   +5 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source