Results 131 to 140 of about 1,230,887 (337)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Epidemiological support for genetic variability at hypothalamic–pituitary–adrenal axis and serotonergic system as risk factors for major depression

Neuropsychiatric Disease and Treatment, 2015
Ana Ching-López,1 Jorge Cervilla,1–3 Margarita Rivera,1–3 Esther Molina,4 Kathryn McKenney,2 Isabel Ruiz-Perez,3,5,6 Miguel Rodríguez-Barranco,5 Blanca Gutiérrez1,21Department of Psychiatry, Institute of Neurosciences ...
Ching-López A, Cervilla J, Rivera M, Molina E, McKenney K, Ruiz-Perez I, Rodríguez-Barranco M, Gutiérrez B   +7 more
doaj  

POPULATION STUDIES IN PREDOMINANTLY SELF-POLLINATED SPECIES. VI. GENETIC VARIABILITY BETWEEN AND WITHIN NATURAL POPULATIONS OF WILD OATS FROM DIFFERING HABITATS IN CALIFORNIA [PDF]

, 1965
A G Imam, R. W. Allard
openalex   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

THE MATING SYSTEM AND GENETIC VARIABILITY IN NATURAL POPULATIONS OF COLLINSIA HETEROPHYLLA [PDF]

, 1964
Jon Weil, R. W. Allard
openalex   +1 more source

Sex and recombination in the H\"otzel aging model

, 2003
Why sex evolved and it prevails in nature remains one of the great puzzles of evolution. Most biologists would explain that it promotes genetic variability, however this explanation suffers from several difficulties. What advantages might sex confer? The
Sousa, A. O.
core   +2 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Genetic Variability of Exotic Sugarcane Genotypes

Scientifica, 2017
Sugarcane is the main sugar producing crop in Bangladesh. However, improvement of this crop through breeding is limited due to lack of genetic diversity.
M. N. Alam, Ujjal Kumar Nath, K. M. R. Karim, M. M. Ahmed, R. Y. Mitul   +4 more
doaj   +1 more source

RELEASE OF GENETIC VARIABILITY THROUGH RECOMBINATION. VII. SECOND AND THIRD CHROMOSOMES OF DROSOPHILA MELANOGASTER [PDF]

, 1961
Eliot B. Spiess, Archie C Allen
openalex   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source