Results 111 to 120 of about 668,410 (314)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Genetic, environmental and stochastic factors in monozygotic twin discordance with a focus on epigenetic differences

, 2012
Genetic-epidemiological studies on monozygotic (MZ) twins have been used for decades to tease out the relative contributions of genes and the environment to a trait.
Morahan, JM, Ramagopalan, SV, Ebers George C, Czyz Witold, Ramagopalan, Sreeram, George C Ebers, Sreeram V Ramagopalan, Ebers, GC, Ramagopalan Sreeram V, Witold Czyz, Julia M Morahan, Morahan Julia M, Ebers, George, Czyz, W   +13 more
core   +1 more source

Characterization and assessment of variability in upland rice collections [PDF]

Electronic Journal of Plant Breeding, 2014
The upland rice accessions are natural reservoir of genetic variability for various biotic and abiotic stresses. Forty eight upland rice germplasm accessions were evaluated and characterized for fourteen quantitative and fifteen qualitative traits ...
Abhishek Singh, A. K. Singh, Shama Parveen and P. K. Singh*
doaj  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Demographic and genetic variability in Cape Dwarf Chameleons, Bradypodion pumilum, withink a fragmented, urban habitat

, 2012
Includes bibliographical references.Habitat fragmentation is recognized as a primary cause of biodiversity loss. To maximize biodiversity maintenance, researchers in the field of conservation biology often investigate population demography and genetic ...
Katz, Eric Michael
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Genetic studies in pigeonpea (Cajanus cajan (L.) Mill sp) [PDF]

Electronic Journal of Plant Breeding, 2011
Study was carried out for genetic variability, heritability and genetic advance of twelve characters in fifty white seed coated lines.High coefficient of variation for number of pods, seed yield per plant, plant height and raceme length and high values ...
D.Bhadru
doaj  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Detection of genetic diversity among Indian strains of _Xanthomonas campestris_ pv. _mangiferaeindicae_ using PCR-RAPD

, 2008
The randomly amplified polymorphic DNA (RAPD) technique was used to investigate the genetic diversity in 6 strains of _Xanthomonas campestris_ pv. _mangiferaeindicae_ (_Xcmi_), the causal pathogen of mango bacterial canker disease (MBCD).
Vijai Kumar Gupta, Ram Kishun
core  

Genetic variability studies in extra large and large seeded kabuli chickpea (Cicer arietinum)

Electronic Journal of Plant Breeding, 2020
Thirty kabuli chickpea genotypes were evaluated in a randomized block design with three replications. Analysis of variance revealed significant genotypic differences for all the nineteen characters with wide range of variability.
B. Manasa, M. Shanthi Priya, V. Jayalakshmi and P. Umamaheswari
doaj   +1 more source