Results 171 to 180 of about 668,410 (314)

Genetics of inherited variability [PDF]

, 2018
Social interactions are common for all living organisms. In animal breeding, these interactions are of interest as they are often a source of indirect genetic effects (IGEs). An IGE is a heritable effect of an individual on the trait value of another individual.
openaire   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Exploring EBNA3C Genetic Variability and Recombination in Epstein-Barr Virus-Associated Cancers. [PDF]

Int J Mol Sci
Barra A, Vasquez-Aguilar P, Braz-Silva PH, Zanella L.   +3 more
europepmc   +1 more source

THE ACCUMULATION OF GENETIC VARIABILITY IN YEAST

Genetics, 1971
C, Blatherwick, C, Wills
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Genetic variability in the leptin-melanocortin pathway and its role in weight loss. [PDF]

Mol Metab
Santos-Pereira M, Guimarães M, Monteiro MP, Pereira SS, Azevedo L.   +4 more
europepmc   +1 more source

THE BOTTLENECK EFFECT AND GENETIC VARIABILITY IN POPULATIONS [PDF]

Evolution, 1975
Masatoshi, Nei, Takeo, Maruyama, Ranajit, Chakraborty   +2 more
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Genetic Variability and Correlation Studies in Brassica Napus L. Genotypes

, 2013
International audienceThis research work was carried out at The University of Agriculture, Peshawar during crop season year 2011-12. The objectives were to study the genetic variability and correlation among different traits in Brassica napus L.
Abideen, Syed Ainul, Noor Ul Abideen, Syed, Nadeem, Faisal   +2 more
core  

ABCG2 Genetic Variability in Drug Exposure and Toxicity: Implications for Clinical Practice. [PDF]

Toxics
Božina T, Šimičević L, Ganoci L, Lovrić M, Klarica Domjanović I, Trkulja V, Božina N.   +6 more
europepmc   +1 more source