Results 181 to 190 of about 668,410 (314)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

The population genetic structure of Portunus pelagicus in Australian waters

, 2004
This thesis describes the results of an investigation into the population genetic structure of the blue swimmer crab, Portunus pelagicus, in Australian waters. P. pelagicus is an Indo-West Pacific species, with adults and juveniles that inhabit sheltered
Sezmiş, Ertuğ
core  

Genetic Variability in the IGF-1 Axis Modulates Cancer-Associated Cachexia and Prognosis. [PDF]

Cancers (Basel)
Moreira Pires M, Guerra de Melo I, Silva ACL, Rocha Dias V, Silva C, Silva MP, M O Santos J, Ferreira T, Tavares V, Medeiros R.   +9 more
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Women with Abdominal Aortic Aneurysms Have a Different Pattern of Genetic Variability, Compared to Men. [PDF]

Biomedicines
Wallinder J, Wanhainen A, Åkerud H, Wågsäter D, Björck M.   +4 more
europepmc   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Maximizing Genetic Response in Breeding Schemes of Dairy Cattle with Constraints on Variance of Response

, 1994
Predicted genetic progress in dairy cattle breeding schemes was maximized with the variances of selection responses constrained, i.e., restricted effective population sizes. This restriction would also lead to schemes with acceptable rates of inbreeding (
Woolliams, John, Meuwissen, T.H.E.
core  

The Distribution and Genetic Variability of Potato Viruses in Russian Regions. [PDF]

Acta Naturae
Samarskaya VO, Butyrin FA, Suprunova TP, Spechenkova NA, Taliansky ME, Kalinina NO.   +5 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Genetic Variability, Trait Association, and Multi-Trait Selection of New Indeterminate Tomato Genotypes Under Protected Cultivation. [PDF]

Plants (Basel)
Shekhar R, Singh AK, Yadav RK, Choudhary H, Asrey R, Mishra GP, Narayanswami B, Chaukhande P, Gainiamliu KG, Mutthuraju C, Kumar R, Pal S, Shaktawat C, Singh N, Singh J.   +14 more
europepmc   +1 more source