Results 201 to 210 of about 233,443 (255)

Fine-Scale Spatial Genetic Structure and Leaf Shape Variation in Five Fagaceae Species: Insights Into Conservation and Adaptation. [PDF]

Ecol Evol
Wang R, Luo Y, Qi M, Zhang Y, Zhang J, Luo Y, Du FK.   +6 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Polygenic risk scores and Parkinson's disease in South Africa advancing ancestry informed disease prediction. [PDF]

PLoS Genet
Step K, Ndong Sima CAA, Grant S, Kim JJ, Waldo E, Bardien S, Mata IF, Global Parkinson’s Genetics Program (GP2).   +7 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Deciphering autosomal and X-linked genetic effects of early growth traits in Murciano-Granadina goats via a multivariate animal model. [PDF]

Vet Anim Sci
Ehsaninia J, Zandi MB, Taned M, Bagheripour A.   +3 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Unveiling the genetic determinants of germination efficiency in common bermudagrass: A genome-wide association study. [PDF]

Plant Genome
Thapa Magar B, Yu S, Xiang M, Tadege M, Wu Y.   +4 more
europepmc   +1 more source

Predictive modeling of sugar beet bolting via vernalization-intensity model and resilience assessment in diverse autumn cultivation environments. [PDF]

PLoS One
Sadeghzadeh Hemayati S, Saremirad A, Nooshkam A, Yar-Ahmadi S, Abdipur M.   +4 more
europepmc   +1 more source

Genetic architecture of seed protein composition in grain amaranth (<i>Amaranthus hypochondriacus</i>): a multi-environment genome-wide association study. [PDF]

Front Nutr
Chauhan R, Prabhakaran S, Joshi DC, Chandora R, Jaiswal JP, Pandey D.   +5 more
europepmc   +1 more source