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Genetic variants associated with sepsis.
PLoS ONE, 2022 BackgroundThe variable presentations and different phenotypes of sepsis suggest that risk of sepsis comes from many genes each having a small effect. The cumulative effect can be used to create individual risk profile.Milo Engoren, Elizabeth S Jewell, Nicholas Douville, Stephanie Moser, Michael D Maile, Melissa E Bauer +5 moredoaj +4 more sourcesPathogenesis of premature coronary artery disease: Focus on risk factors and genetic variants
Genes and Diseases, 2022 The development of premature coronary artery disease (PCAD) is dependent on both genetic predisposition and traditional risk factors. Strategies for unraveling the genetic basis of PCAD have evolved with the advent of modern technologies.Haiming Wang, Zifan Liu, Junjie Shao, Min Jiang, Xuechun Lu, Lejian Lin, Lin Wang, Qiang Xu, Haomin Zhang, Xin Li, Jingjing Zhou, Yundai Chen, Ran Zhang +12 moredoaj +1 more sourceA saturated map of common genetic variants associated with human height
Nature, 2022 Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1.L. Yengo, S. Vedantam, E. Marouli, J. Sidorenko, Eric Bartell, S. Sakaue, M. Graff, A. Eliasen, Yunxuan Jiang, S. Raghavan, J. Miao, J. D. Arias, R. E. Mukamel, Cassandra N. Spracklen, X. Yin, Shyh-Huei Chen, T. Ferreira, JI Yingjie, Tugce Karedera, K. Lüll, Kuang Lin, Deborah E. Malden, C. Medina-Gomez, Moara Machado, Amy Moore, S. Rüeger, T. Ahluwalia, M. Akiyama, M. Allison, Marcus Alvarez, M. K. Andersen, Alireza Ani, Vivek Appadurai, L. Arbeeva, Seema Bhaskar, L. Bielak, S. Bollepalli, L. Bonnycastle, J. Bork-Jensen, J. Bradfield, Y. Bradford, P. Braund, J. Brody, K. Burgdorf, B. Cade, H. Cai, Q. Cai, A. Campbell, M. Cañadas-Garre, E. Catamo, Jin-Fang Chai, Xiaoran Chai, Li Chang, Yipeng Chang, Chien-Hsiun Chen, A. Chesi, S. Choi, R. Chung, M. Cocca, M. P. Concas, C. Couture, G. Cuéllar-Partida, Rebecca D. Danning, E. W. Daw, Frauke Degenhard, G. Delgado, A. Delitala, A. Demirkan, Xuan Deng, P. Devineni, Alexander Dietl, M. Dimitriou, Latchezar Dimitrov, R. Dorajoo, A. Ekici, J. Engmann, Z. Fairhurst-Hunter, Aliki-Eleni Farmaki, J. Faul, J. Fernández-López, L. Forer, Margherita Francescatto, S. Freitag-Wolf, C. Fuchsberger, T. Galesloot, Yan Gao, Zishan Gao, F. Geller, O. Giannakopoulou, F. Giulianini, A. Gjesing, A. Goel, S. Gordon, Mathias Gorski, S. Graham, J. Grove, Xiuqing Guo, S. Gustafsson, J. Haessler, T. Hansen, A. Havulinna, S. Haworth, Jing He, N. Heard-Costa, Prashantha Hebbar, G. Hindy, Y. Ho, E. Hofer, E. Holliday, K. Horn, W. Hornsby, J. Hottenga, Hongyan Huang, Jie Huang, A. Huerta-Chagoya, J. Huffman, Y. Hung, Shaofeng Huo, M. Y. Hwang, Hiroyuki Iha, Daisuke D Ikeda, M. Isono, A. Jackson, S. Jäger, I. Jansen, I. Johansson, J. Jonas, A. Jonsson, T. Jørgensen, I. Kalafati, M. Kanai, S. Kanoni, L. Kårhus, A. Kasturiratne, T. Katsuya, T. Kawaguchi, R. Kember, K. Kentistou, Han-Na Kim, Y. J. Kim, M. Kleber, M. Knol, A. Kurbasic, M. Lauzon, P. Le, R. Lea, Jong-Young Lee, H. Leonard, Shengchao A Li, Xiaohui Li, Xiaoyin Li, Jin-Zhao Liang, Honghuang Lin, Shih-Yi Lin, Jun Liu, Xueping Liu, K. S. Lo, J. Long, L. Lorés-Motta, J. Luan, V. Lyssenko, L. Lyytikäinen, A. Mahajan, Vasiliki Mamakou, M. Mangino, A. Manichaikul, J. Marten, M. Mattheisen, L. Mavarani, Aaron F. McDaid, K. Meidtner, Tori L. Melendez, J. Mercader, Y. Milaneschi, Jason E. Miller, I. Millwood, Pashupati P. Mishra, R. Mitchell, L. Møllehave, A. Morgan, Soeren Mucha, M. Munz, M. Nakatochi, C. Nelson, M. Nethander, C. Nho, A. A. Nielsen, I. Nolte, Suraj S Nongmaithem, R. Noordam, I. Ntalla, T. Nutile, Anita Pandit, P. Christofidou, Katri Pärna, Marc Pauper, Eva R. B. Petersen, L. Petersen, N. Pitkänen, O. Polašek, A. Poveda, Michael H. Preuss, S. Pyarajan, L. Raffield, H. Rakugi, J. Ramírez, A. Rasheed, Dennis Raven, N. W. Rayner, C. Riveros, Rebecca R. Rohde, D. Ruggiero, S. Ruotsalainen, K. Ryan, M. Sabater-Lleal, R. Saxena, M. Scholz, A. Sendamarai, Botong Shen, Jingchunzi Shi, J. Shin, C. Sidore, X. Sim, C. Sitlani, R. Slieker, R. Smit, A. Smith, Jennifer A. Smith, L. Smyth, L. Southam, V. Steinthorsdottir, Liang Sun, F. Takeuchi, Divya Sri Priyanka Tallapragada, K. Taylor, B. Tayo, C. Tcheandjieu, N. Terzikhan, P. Tesolin, A. Teumer, E. Theusch, Deborah J. Thompson, G. Thorleifsson, P. Timmers, S. Trompet, Constance Turman, S. Vaccargiu, S. W. van der Laan, P. J. van der Most, J. V. van Klinken, J. van Setten, S. Verma, N. Verweij, Yogasudha Veturi, Carol A. Wang, Chaolong Wang, Lihua Wang, Zhe Wang, H. Warren, Wenjie Wei, A. R. Wickremasinghe, M. Wielscher, K. Wiggins, B. Winsvold, A. Wong, Yang Wu, M. Wuttke, Rui Xia, Tian Xie, Ken Yamamoto, Jingyun Yang, Jie Yao, Hannah Young, N. Yousri, Lei Yu, Lingyao Zeng, Weihua Zhang, Xinyuan Zhang, Jinghua Zhao, Wei Zhao, Wei Zhou, M. Zimmermann, M. Zoledziewska, L. Adair, H. Adams, C. Aguilar-Salinas, F. Al-Mulla, D. Arnett, F. Asselbergs, B. Åsvold, J. Attia, B. Banas, S. Bandinelli, David A. Bennett, T. Bergler, D. Bharadwaj, G. Biino, H. Bisgaard, E. Boerwinkle, C. Böger, K. Bønnelykke, D. Boomsma, A. Børglum, J. Borja, C. Bouchard, D. Bowden, I. Brandslund, B. Brumpton, J. Buring, M. Caulfield, J. Chambers, G. Chandak, S. Chanock, N. Chaturvedi, Y. Chen, Zhengming Chen, Ching-Yu Cheng, I. Christophersen, M. Ciullo, J. Cole, F. Collins, Richard S. Cooper, M. Cruz, F. Cucca, L. Cupples, M. Cutler, S. Damrauer, T. Dantoft, G. Borst, L. D. de Groot, P. D. De Jager, D. D. de Kleijn, H. J. de Silva, G. Dedoussis, A. D. den Hollander, S. Du, D. Easton, P. Elders, A. Eliassen, P. Ellinor, S. Elmståhl, J. Erdmann, M. Evans, D. Fatkin, B. Feenstra, M. Feitosa, L. Ferrucci, I. Ford, M. Fornage, A. Franke, P. Franks, B. Freedman, P. Gasparini, C. Gieger, G. Girotto, M. Goddard, Y. Golightly, C. González‐Villalpando, P. Gordon-Larsen, H. Grallert, S. Grant, N. Grarup, Lyn R. Griffiths, L. Groop, V. Gudnason, C. Haiman, H. Hakonarson, T. Hansen, C. Hartman, A. Hattersley, C. Hayward, S. Heckbert, C. Heng, C. Hengstenberg, A. Hewitt, H. Hishigaki, C. Hoyng, Paul L. Huang, Wei Huang, S. Hunt, K. Hveem, E. Hyppönen, W. Iacono, S. Ichihara, M. A. Ikram, C. Isasi, R. Jackson, M. Jarvelin, Zidan Jin, K. Jöckel, Peter K. Joshi, P. Jousilahti, J. Jukema, M. Kähönen, Y. Kamatani, K. Kang, J. Kaprio, S. Kardia, F. Karpe, N. Kato, F. Kee, T. Kessler, A. Khera, C. Khor, L. Kiemeney, Bong-Jo Kim, EunGyul Kim, Hyung-Lae Kim, P. Kirchhof, M. Kivimaki, W. Koh, H. Koistinen, G. Kolovou, J. Kooner, C. Kooperberg, A. Köttgen, P. Kovacs, A. Kraaijeveld, P. Kraft, R. Krauss, M. Kumari, Z. Kutalik, M. Laakso, L. Lange, C. Langenberg, L. Launer, L. Marchand, Hyejin Lee, N. Lee, T. Lehtimäki, Huaixing Li, Liming Li, W. Lieb, Xu Lin, L. Lind, A. Linneberg, Ching‐Ti Liu, J. Liu, M. Loeffler, B. London, S. Lubitz, Stephen Lye, D. Mackey, R. Mägi, P. Magnusson, G. Marcus, P. M. Vidal, N. G. Martin, W. März, F. Matsuda, R. McGarrah, M. McGue, A. McKnight, S. Medland, D. Mellström, A. Metspalu, B. Mitchell, P. Mitchell, D. Mook-Kanamori, A. Morris, L. Mucci, P. Munroe, M. Nalls, S. Nazarian, A. Nelson, M. Neville, C. Newton‐Cheh, C. Nielsen, M. Nöthen, C. Ohlsson, A. Oldehinkel, L. Orozco, K. Pahkala, P. Pajukanta, C. Palmer, E. Parra, C. Pattaro, O. Pedersen, C. Pennell, B. Penninx, L. Pérusse, A. Peters, P. Peyser, D. Porteous, D. Posthuma, C. Power, P. Pramstaller, M. Province, Q. Qi, J. Qu, D. Rader, O. Raitakari, S. Ralhan, L. Rallidis, D. Rao, S. Redline, Dermot F. Reilly, A. Reiner, S. Rhee, P. Ridker +499 moresemanticscholar +1 more sourceGenetic Variants of SARS-CoV-2-What Do They Mean?
Journal of the American Medical Association (JAMA), 2021 Over the course of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, the clinical, scientific, and public health communities have had to respond to new viral genetic variants. Each one has triggered a flurry of media attention, a A. Lauring, E. Hodcroftsemanticscholar +1 more sourceInteraction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia
JAMA psychiatry, 2022 Key Points Question Can common genetic variants be used to differentiate between treatment-resistant schizophrenia (TRS) and other forms of this disorder?A. Pardiñas, S. Smart, I. Willcocks, P. Holmans, Charlotte A Dennison, A. Lynham, S. Legge, B. Baune, T. Bigdeli, Murray J. Cairns, A. Corvin, A. Fanous, J. Frank, B. Kelly, A. McQuillin, I. Melle, P. Mortensen, B. Mowry, C. Pato, S. Periyasamy, M. Rietschel, D. Rujescu, C. Simonsen, D. St. Clair, P. Tooney, J. Wu, O. Andreassen, K. Kowalec, Patrick F. Sullivan, R. Murray, M. Owen, J. MacCabe, M. O’Donovan, J. Walters, O. Ajnakina, Luis Alameda, T. Barnes, D. Berardi, E. Bonora, Sara Camporesi, M. Cleusix, P. Conus, B. Crespo-Facorro, G. D’Andrea, A. Demjaha, K. Do, G. Doody, C. Eap, A. Ferchiou, M. di Forti, L. Guidi, L. Homman, R. Jenni, E. Joyce, L. Kassoumeri, I. Khadimallah, O. Lastrina, R. Muratori, H. Noyan, F. O’Neill, B. Pignon, Romeo Restellini, J. Richard, F. Schürhoff, F. Španiel, A. Szöke, I. Tarricone, A. Tortelli, A. Üçok, J. Vázquez-Bourgon +69 moresemanticscholar +1 more sourceGenetic variants associated with longitudinal changes in brain structure across the lifespan
Nature Neuroscience, 2021 Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases.R. Brouwer, M. Klein, K. Grasby, H. Schnack, N. Jahanshad, J. Teeuw, S. Thomopoulos, E. Sprooten, C. Franz, N. Gogtay, W. Kremen, M. Panizzon, Loes M. Olde Loohuis, C. Whelan, M. Aghajani, C. Alloza, D. Alnæs, E. Artiges, R. Ayesa-Arriola, G. Barker, M. Bastin, E. Blok, E. Bøen, I. Breukelaar, Joanna K. Bright, Elizabeth E. L. Buimer, R. Bülow, D. Cannon, S. Ciufolini, N. Crossley, C. Damatac, P. Dazzan, C. L. de Mol, S. D. de Zwarte, S. Desrivières, C. Díaz-Caneja, N. T. Doan, K. Dohm, J. Fröhner, J. Goltermann, A. Grigis, D. Grotegerd, Laura K. M. Han, M. Harris, C. Hartman, Sarah J Heany, W. Heindel, D. Heslenfeld, S. Hohmann, B. Ittermann, P. Jansen, J. Janssen, T. Jia, Jiyang Jiang, C. Jockwitz, T. Karali, D. Keeser, M. Koevoets, R. Lenroot, B. Malchow, R. Mandl, Vicente Medel, S. Meinert, Catherine A. Morgan, Thomas W. Mühleisen, L. Nabulsi, N. Opel, V. O. de la Foz, B. Overs, M. Martinot, E. Quinlan, R. Redlich, T. Marques, J. Repple, G. Roberts, Gennady V. Roshchupkin, N. Setiaman, E. Shumskaya, F. Stein, G. Sudre, S. Takahashi, A. Thalamuthu, D. Tordesillas-Gutiérrez, A. van der Lugt, N. V. van Haren, J. Wardlaw, W. Wen, H. Westeneng, K. Wittfeld, A. Zhu, A. Zugman, N. Armstrong, Gaia Bonfiglio, J. Bralten, S. Dalvie, G. Davies, M. di Forti, L. Ding, G. Donohoe, A. Forstner, J. González-Peñas, Joao Guimaraes, G. Homuth, J. Hottenga, M. Knol, J. Kwok, S. Le Hellard, K. Mather, Y. Milaneschi, D. Morris, M. Nöthen, S. Papiol, M. Rietschel, M. Santoro, V. Steen, J. Stein, F. Streit, Rick M. Tankard, A. Teumer, D. van ‘t Ent, D. van der Meer, K. van Eijk, E. Vassos, J. Vázquez-Bourgon, S. Witt, H. Adams, I. Agartz, D. Ames, K. Amunts, O. Andreassen, C. Arango, T. Banaschewski, B. Baune, S. Belangero, A. Bokde, D. Boomsma, R. Bressan, H. Brodaty, J. Buitelaar, W. Cahn, S. Caspers, S. Cichon, B. C. Facorro, S. Cox, U. Dannlowski, T. Elvsåshagen, T. Espeseth, P. Falkai, S. Fisher, Herta Flor, J. Fullerton, H. Garavan, P. Gowland, H. Grabe, T. Hahn, A. Heinz, M. Hillegers, J. Hoare, P. Hoekstra, M. Ikram, A. Jackowski, A. Jansen, E. Jönsson, R. Kahn, T. Kircher, M. Korgaonkar, A. Krug, H. Lemaître, U. Malt, J. Martinot, C. Mcdonald, P. Mitchell, R. Muetzel, R. Murray, F. Nees, I. Nenadić, J. Oosterlaan, R. Ophoff, P. Pan, B. Penninx, L. Poustka, P. Sachdev, G. Salum, P. Schofield, G. Schumann, Philip Shaw, K. Sim, M. Smolka, Dan J Stein, J. Trollor, L. H. van den Berg, J. Veldink, H. Walter, L. Westlye, R. Whelan, T. White, M. Wright, S. Medland, B. Franke, P. Thompson, H. H. Hulshoff Pol +200 moresemanticscholar +1 more source
