Results 91 to 100 of about 4,753,986 (376)

The contribution of common regulatory and protein-coding TYR variants to the genetic architecture of albinism [PDF]

, 2022
Vincent Michaud, Eulalie Lasseaux, David Green, Dave T. Gerrard, Claudio Plaisant, Tomas Fitzgerald, Ewan Birney, Benoı̂t Arveiler, Graeme C. Black, Panagiotis I. Sergouniotis   +9 more
openalex   +1 more source

Association of genetic variants with dyslipidemia

Molecular Medicine Reports, 2015
Although genetic variants, which regulate lipid metabolism, have been extensively investigated in Caucasian populations, the genes, which confer susceptibility to dyslipidemia in Japanese individuals, remain to be elucidated. The aim of the present study was to examine a possible association among hypertriglyceridemia, hypo‑high density lipoprotein ...
Shintaro, Abe, Fumitaka, Tokoro, Reiko, Matsuoka, Masazumi, Arai, Toshiyuki, Noda, Sachiro, Watanabe, Hideki, Horibe, Tetsuo, Fujimaki, Mitsutoshi, Oguri, Kimihiko, Kato, Shinya, Minatoguchi, Yoshiji, Yamada   +11 more
openaire   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

ERAP1 Gene Variants and Haplotypes Associated With Psoriasis Vulgaris of Han Chinese in Inner Mongolia

Molecular Genetics & Genomic Medicine
Background This study aimed to investigate the association between genetic variants of ERAP1 (OMIM: 606832) and psoriasis vulgaris (PsV) susceptibility in Inner Mongolia Han nationality.
Xin Li, Jia Bao, Liya Ai, Fan‐Rui Yang, Bo Yu, Yan‐Ping Huang, Na Li, Wen‐Yuan Ding, Zhi‐Qiang Sun, Xin‐Xiang Lv, Jian‐Wen Han   +10 more
doaj   +1 more source

Genome-wide association study identifies 48 common genetic variants associated with handedness

bioRxiv, 2019
Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders.
Gabriel Cuellar Partida, J. Tung, N. Eriksson, E. Albrecht, F. Aliev, O. Andreassen, I. Barroso, J. Beckmann, M. Boks, D. Boomsma, H. Boyd, M. Breteler, H. Campbell, D. Chasman, L. Cherkas, G. Davies, E. D. de Geus, I. Deary, P. Deloukas, D. Dick, D. Duffy, J. Eriksson, T. Esko, B. Feenstra, F. Geller, C. Gieger, I. Giegling, S. Gordon, Jiali Han, T. Hansen, A. Hartmann, C. Hayward, K. Heikkilä, A. Hicks, J. Hirschhorn, J. Hottenga, J. Huffman, Liang-Dar Hwang, M. Ikram, J. Kaprio, J. Kemp, K. Khaw, N. Klopp, B. Konte, Z. Kutalik, J. Lahti, Xin Li, R. Loos, M. Luciano, S. Magnusson, M. Mangino, P. Marques-Vidal, N. Martin, W. McArdle, M. McCarthy, C. Medina-Gomez, M. Melbye, Scott A. Melville, A. Metspalu, L. Milani, V. Mooser, M. Nelis, D. Nyholt, K. O’Connell, R. Ophoff, Cameron D. Palmer, A. Palotie, T. Palviainen, G. Paré, L. Paternoster, L. Peltonen, B. Penninx, O. Polašek, P. Pramstaller, I. Prokopenko, K. Raikkonen, S. Ripatti, F. Rivadeneira, I. Rudan, D. Rujescu, J. Smit, G. Smith, J. Smoller, N. Soranzo, T. Spector, Beate St Pourcain, J. Starr, H. Stefánsson, S. Steinberg, M. Teder-Laving, G. Thorleifsson, K. Stefánsson, N. Timpson, A. Uitterlinden, C. V. van Duijn, F. V. van Rooij, J. M. Vink, P. Vollenweider, E. Vuoksimaa, G. Waeber, N. Wareham, N. Warrington, D. Waterworth, T. Werge, H. Wichmann, E. Widén, G. Willemsen, A. Wright, M. Wright, Mousheng Xu, J. Zhao, P. Kraft, D. Hinds, C. Lindgren, R. Magi, B. Neale, David M. Evans, S. Medland   +117 more
semanticscholar   +1 more source

Characterizing genetic variants for clinical action [PDF]

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 2014
Genome‐wide association studies, DNA sequencing studies, and other genomic studies are finding an increasing number of genetic variants associated with clinical phenotypes that may be useful in developing diagnostic, preventive, and treatment strategies for individual patients.
Erin M. Ramos, Corina Din‐Lovinescu, Jonathan S. Berg, Lisa D. Brooks, Audrey Duncanson, Michael Dunn, Peter Good, Tim J.P. Hubbard, Gail P. Jarvik, Christopher O'Donnell, Stephen T. Sherry, Naomi Aronson, Leslie G. Biesecker, Bruce Blumberg, Ned Calonge, Helen M. Colhoun, Robert S. Epstein, Paul Flicek, Erynn S. Gordon, Eric D. Green, Robert C. Green, Matthew Hurles, Kensaku Kawamoto, William Knaus, David H. Ledbetter, Howard P. Levy, Elaine Lyon, Donna Maglott, Howard L. McLeod, Nazneen Rahman, Gurvaneet Randhawa, Catherine Wicklund, Teri A. Manolio, Rex L. Chisholm, Marc S. Williams   +34 more
openaire   +3 more sources

CCT4 promotes tunneling nanotube formation

FEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto, Akiko Asada, Taro Saito, Kanae Ando   +3 more
wiley   +1 more source

Evidence for the role of EPHX2 gene variants in anorexia nervosa. [PDF]

, 2013
Anorexia nervosa (AN) and related eating disorders are complex, multifactorial neuropsychiatric conditions with likely rare and common genetic and environmental determinants.
Bansal, V, Berenson, G, Bergen, AW, Berrettini, W, Bloss, CS, Brandt, H, Bulik, CM, Carson, A, Chen, W, Crawford, S, Crow, S, Darst, BF, Duvvuri, V, Fichter, MM, Galvez, L, Halmi, KA, Johnson, C, Kaplan, AS, Kaye, W, Keel, P, Klump, KL, La Via, M, Levy, S, Libiger, O, Lilenfeld, L, Magistretti, P, Mitchell, JE, Murray, S, Pham, P, Phillips, T, Plotnicov, K, Rotondo, A, Schork, NJ, Scott-Van Zeeland, AA, Shih, PB, Smith, EN, Srinivasan, S, Strober, M, Tewhey, R, Tisch, R, Topol, EJ, Torkamani, A, Treasure, J, Villarasa, N, Wineinger, N, Woodside, DB, Zhang, G   +46 more
core   +1 more source

Pharmacogenomics of Novel Direct Oral Anticoagulants: Newly Identified Genes and Genetic Variants

Journal of Personalized Medicine, 2019
Direct oral anticoagulants (DOAC) have shown an upward prescribing trend in recent years due to favorable pharmacokinetics and pharmacodynamics without requirement for routine coagulation monitoring.
Sri H. Kanuri, R. Kreutz
semanticscholar   +1 more source

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

FEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii, Edoardo Andrea Cutolo, Daniele Montepietra, Claudia Battarra, Roberto Caferri, Stefano Capaldi, Zeno Guardini, Luca Dall'Osto, Roberto Bassi   +8 more
wiley   +1 more source