Results 111 to 120 of about 4,753,986 (376)

Relationship between APOE, PER2, PER3 and OX2R Genetic Variants and Neuropsychiatric Symptoms in Patients with Alzheimer’s Disease [PDF]

, 2023
Susana Lozano-Tovar, Yaneth Rodríguez‐Agudelo, David José Dávila‐Ortiz de Montellano, Blanca Estela Pérez-Aldana, Alberto Ortega‐Vázquez, Nancy Monroy‐Jaramillo   +5 more
openalex   +1 more source

Genetic Variants Associated With Cancer Therapy–Induced Cardiomyopathy

Circulation, 2019
Supplemental Digital Content is available in the text.
P. García-Pavía, Yuri Kim, M. A. Restrepo-Córdoba, I. Lunde, H. Wakimoto, A. Smith, Christopher N Toepfer, K. Getz, J. Gorham, Parth N. Patel, Kaoru Ito, J. A. Willcox, Z. Arany, Jian Li, A. Owens, R. Govind, B. Nuñez, Erica Mazaika, A. Bayés‐Genís, R. Walsh, B. Finkelman, J. Lupón, N. Whiffin, I. Serrano, W. Midwinter, Alicja E Wilk, A. Bardají, N. Ingold, R. Buchan, U. Tayal, D. Pascual-Figal, A. de Marvao, Mian Ahmad, J. M. García-Pinilla, A. Pantazis, F. Domínguez, A. John Baksi, D. O’Regan, S. Rosen, S. Prasad, E. Lara-Pezzi, M. Provencio, A. Lyon, L. Alonso-Pulpón, S. Cook, S. DePalma, P. Barton, R. Aplenc, J. Seidman, B. Ky, J. Ware, C. Seidman   +51 more
semanticscholar   +1 more source

Genetic Variants in Pre-Eclampsia [PDF]

Obstetrical & Gynecological Survey, 2013
BACKGROUND Pre-eclampsia has a clear familial component, suggesting that the condition may be partly attributable to genetic susceptibility. The search for susceptibility genes has led to a drastic increase in the number of published studies associating genetic factors with pre-eclampsia.
Buurma, A.J., Turner, R.J., Driessen, J.H.M., Mooyaart, A.L., Schoones, J.W., Bruijn, J.A., Bloemenkamp, K.W.M., Dekkers, O.M., Baelde, H.J.   +8 more
openaire   +4 more sources

Vacuolar transport and function of Saccharomyces cerevisiae sterol ester hydrolase Tgl1

FEBS Letters, EarlyView.
Tgl1, one of yeast sterol ester hydrolases, had been found on the lipid droplets where sterol esters are mainly stored. This study revealed that Tgl1 is transported into the vacuole depending on the ESCRT‐I–III complex, and that it exhibits intra‐vacuolar sterol ester hydrolase activity.
Takumi Nakatsuji, Kosuke Shiraishi, Chuqian Wang, Hiroya Yurimoto, Yasuyoshi Sakai, Masahide Oku   +5 more
wiley   +1 more source

Integrating rare genetic variants into pharmacogenetic drug response predictions

Human Genomics, 2018
Variability in genes implicated in drug pharmacokinetics or drug response can modulate treatment efficacy or predispose to adverse drug reactions. Besides common genetic polymorphisms, recent sequencing projects revealed a plethora of rare genetic ...
M. Ingelman-Sundberg, S. Mkrtchian, Yitian Zhou, V. Lauschke   +3 more
semanticscholar   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Stroke genetics: prospects for personalized medicine. [PDF]

, 2012
Epidemiologic evidence supports a genetic predisposition to stroke. Recent advances, primarily using the genome-wide association study approach, are transforming what we know about the genetics of multifactorial stroke, and are identifying novel stroke ...
A Gschwendtner, A Hassan, A Helgadottir, A Helgadottir, A Joutel, A Viswanathan, AB Singleton, AJ Bowes, AV Shirodkar, B Rohrer, C Bellenguez, CAPRIE Steering Committee, CS Ku, D Sibbing, DF Gudbjartsson, DJ Klionsky, DK Wysowski, DL Bhatt, DR Holmes Jr, DS Budnitz, E Flossmann, G Paré, HC Diener, HS Markus, HS Markus, Hugh S Markus, J Hardy, JA Johnson, JB Olesen, JF Meschia, JL Mega, JN Hirschhorn, JT O'Brien, L Wang, M Dichgans, M Kubo, M Serizawa, MA Ikram, MV Holmes, P Jerrard-Dunne, P Kraft, P Polychronopoulos, PC Ng, RL Sacco, RS Epstein, S Bevan, S Gretarsdottir, S Gretarsdottir, S Lanfranconi, S Olsson, S Seshadri, S Seshadri, SE Nissen, The International Warfarin Pharmacogenetics Consortium, VG Manolopoulos, VL Roger   +55 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects. [PDF]

, 2020
Genetic variants are the primary driver of congenital heart disease (CHD) pathogenesis. However, our ability to identify causative variants is limited.
Bernstein, Daniel, Bisgrove, Brent W, Brueckner, Martina, Chung, Wendy K, Deanfield, John, Demarest, Bradley, Edwards, Jonathan J, Fernandez, Nicolas F, Gelb, Bruce D, Giardini, Alessandro, Goldmuntz, Elizabeth, Kim, Richard, Lachmann, Alexander, Lifton, Richard P, Ma'ayan, Avi, Newburger, Jane W, Porter, George, Roberts, Amy E, Rouillard, Andrew D, Seidman, Christine E, Shankaran, Sunita S, Srivastava, Deepak, Tristani-Firouzi, Martin, Turan, Nahid, Wang, Zichen, Yost, H Joseph   +25 more
core  

Factorial Mendelian randomization: using genetic variants to assess interactions

bioRxiv, 2019
Background Factorial Mendelian randomization is the use of genetic variants to answer questions about interactions. Although the approach has been used in applied investigations, little methodological advice is available on how to design or perform a ...
Jessica M B Rees, Christopher N. Foley, S. Burgess   +2 more
semanticscholar   +1 more source