Results 141 to 150 of about 4,615,445 (390)

Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines

Genome Medicine, 2018
BackgroundHumoral immune responses to infectious agents or vaccination vary substantially among individuals, and many of the factors responsible for this variability remain to be defined. Current evidence suggests that human genetic variation influences (
P. Scepanovic, Cécile Alanio, C. Hammer, F. Hodel, Jacob Bergstedt, E. Patin, C. Thorball, N. Chaturvedi, B. Charbit, L. Abel, L. Quintana-Murci, D. Duffy, M. Albert, J. Fellay   +13 more
semanticscholar   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Association between venous thromboembolism‐associated genetic variants, coagulation factor levels, and thrombin generation potential

eJHaem
Recently three large meta‐analyses of genome‐wide association studies for venous thromboembolism (VTE) identified over 130 genetic variants. However, mechanisms by which newly identified and therefore underexplored VTE‐associated genetic variants ...
Jihee Han, Ruifang Li‐Gao, Renée deMutsert, Frits R. Rosendaal, Astrid vanHylckama Vlieg   +4 more
doaj   +1 more source

Genetic Variants Associated with Hypertension Risk: Progress and Implications

Pulse
Background: Genetic variants causing diseases with hypertension as a secondary feature have previously been identified. Studies focussing on primary hypertension have utilised common and latterly rare genetic variants in attempts to elucidate the genetic
David Curtis
doaj   +1 more source

Association Between Low-Density Lipoprotein Cholesterol-Lowering Genetic Variants and Risk of Type 2 Diabetes: A Meta-analysis.

Journal of the American Medical Association (JAMA), 2016
Importance Low-density lipoprotein cholesterol (LDL-C)-lowering alleles in or near NPC1L1 or HMGCR, encoding the respective molecular targets of ezetimibe and statins, have previously been used as proxies to study the efficacy of these lipid-lowering ...
L. Lotta, S. Sharp, S. Burgess, J. Perry, I. Stewart, Sara M. Willems, J. Luan, E. Ardanaz, L. Arrióla, B. Balkau, H. Boeing, P. Deloukas, N. Forouhi, P. Franks, S. Grioni, R. Kaaks, T. Key, C. Navarro, P. Nilsson, K. Overvad, D. Palli, S. Panico, J. Quirós, E. Riboli, O. Rolandsson, C. Sacerdote, Elena C Salamanca, N. Slimani, A. Spijkerman, A. Tjønneland, R. Tumino, D. van der A, Y. T. van der Schouw, M. McCarthy, I. Barroso, S. O’Rahilly, D. Savage, N. Sattar, C. Langenberg, R. Scott, N. Wareham   +40 more
semanticscholar   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

Personalized Interpretation and Clinical Translation of Genetic Variants Associated With Cardiomyopathies

Frontiers in Genetics, 2019
Cardiomyopathies are a heterogeneous group of inherited cardiac diseases characterized by progressive myocardium abnormalities associated with mechanical and/or electrical dysfunction. Massive genetic sequencing technologies allow a comprehensive genetic
Oscar Campuzano, Oscar Campuzano, Oscar Campuzano, Oscar Campuzano, Anna Fernandez-Falgueras, Georgia Sarquella-Brugada, Georgia Sarquella-Brugada, Sergi Cesar, Elena Arbelo, Elena Arbelo, Ana García-Álvarez, Paloma Jordà, Monica Coll, Victoria Fiol, Anna Iglesias, Anna Iglesias, Alexandra Perez-Serra, Alexandra Perez-Serra, Jesus Mates, Bernat del Olmo, Carles Ferrer, Mireia Alcalde, Mireia Alcalde, Marta Puigmulé, Irene Mademont-Soler, Ferran Pico, Laura Lopez, Coloma Tiron, Josep Brugada, Josep Brugada, Josep Brugada, Ramon Brugada, Ramon Brugada, Ramon Brugada, Ramon Brugada   +34 more
doaj   +1 more source

GemTools: A fast and efficient approach to estimating genetic ancestry [PDF]

, 2011
To uncover the genetic basis of complex disease, individuals are often measured at a large number of genetic variants (usually SNPs) across the genome. GemTools provides computationally efficient tools for modeling genetic ancestry based on SNP genotypes.
Devlin, Bernie, Kent, Brian P., Klei, Lambertus, Melhem, Nadine, Roeder, Kathryn   +4 more
core  

PANTHER-PSEP: predicting disease-causing genetic variants using position-specific evolutionary preservation

Bioinform., 2016
UNLABELLED PANTHER-PSEP is a new software tool for predicting non-synonymous genetic variants that may play a causal role in human disease. Several previous variant pathogenicity prediction methods have been proposed that quantify evolutionary ...
Haiming Tang, P. Thomas
semanticscholar   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source