Results 21 to 30 of about 649,887 (338)
Sample size requirements to detect the effect of a group of genetic variants in case-control studies
Emerging Themes in Epidemiology, 2008 Background Because common diseases are caused by complex interactions among many genetic variants along with environmental risk factors, very large sample sizes are usually needed to detect such effects in case-control studies. Nevertheless, many genetic
Khoury Muin J +2 more
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Pathogenesis of premature coronary artery disease: Focus on risk factors and genetic variants
Genes and Diseases, 2022 The development of premature coronary artery disease (PCAD) is dependent on both genetic predisposition and traditional risk factors. Strategies for unraveling the genetic basis of PCAD have evolved with the advent of modern technologies.
Haiming Wang +12 more
doaj
HUMAN GENETIC VARIANTS AND THEIR ANALYSIS: CURRENT STATE AND FUTURE PERSPECTIVES
Slovenska pediatrija, 2020 Human genetic variants occur throughout the whole genome, both in the coding and non-coding regions. In addition to defining genetic diversity among individuals, they may, in some instances, cause various genetic diseases, many of which have their onset ...
Lara Slavec +3 more
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International Journal of Bipolar Disorders, 2023 Background Bipolar disorder (BD) and schizophrenia (SZ) are complex psychotic disorders (PSY), with both environmental and genetic factors including possible maternal inheritance playing a role.
Ryobu Tachi +13 more
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Scientific Reports, 2021 Genetic variants causing underlying pharmacogenetic and disease phenotypes have been used as the basis for clinical decision-making. However, due to the lack of standards for next-generation sequencing (NGS) pipelines, reproducing genetic variants among ...
Jeong Hoon Lee +2 more
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Rare Variants in Transcript and Potential Regulatory Regions Explain a Small Percentage of the Missing Heritability of Complex Traits in Cattle. [PDF]
PLoS ONE, 2015 The proportion of genetic variation in complex traits explained by rare variants is a key question for genomic prediction, and for identifying the basis of "missing heritability"--the proportion of additive genetic variation not captured by common ...
Oscar Gonzalez-Recio +6 more
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Novel genetic variants data for adaptation to hypoxia in native chickens
BMC Research Notes, 2023 Objective The genomic response and the role of genetic variants in hypoxia condition are always interesting issues about adaption pathways at genomic level.
Atieh Moradi +4 more
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A Regression-based Approach to Robust Estimation and Inference for Genetic Covariance [PDF]
arXiv, 2021 Genome-wide association studies (GWAS) have identified thousands of genetic variants associated with complex traits, and some variants are shown to be associated with multiple complex traits. Genetic covariance between two traits is defined as the underlying covariance of genetic effects and can be used to measure the shared genetic architecture.
arxiv
Genetic Variants And Atherosclerosis
, 2009 {"references": ["Maton, Anthea, Roshan L,et al. Human Biology and Health. Englewood\nCliffs, New Jersey, USA: Prentice Hall. (1993); ISBN 0-13-981176-1.\nOCLC 32308337", "Ridker PM. Inflammation, atherosclerosis, and cardiovascular risk: an\nepidemiologic view. Blood Coagul Fibrinolysis.
M. Seifi +7 more
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Substrate Specificity of CYP2D6 Genetic Variants
Pharmacogenomics, 2021 Genetic variation in the gene encoding CYP2D6 is used to guide drug prescribing in clinical practice. However, genetic variants in CYP2D6 show substrate-specific effects that are currently not accounted for. With a systematic literature, we retrieved 22 original studies describing in vitro experiments focusing on CYP2D6 alleles (CYP2D6*1, *2, *10 and ...
Lee, M. van der +2 more
openaire +3 more sources