Results 41 to 50 of about 4,615,445 (390)

Sample size requirements to detect the effect of a group of genetic variants in case-control studies

Emerging Themes in Epidemiology, 2008
Background Because common diseases are caused by complex interactions among many genetic variants along with environmental risk factors, very large sample sizes are usually needed to detect such effects in case-control studies. Nevertheless, many genetic
Khoury Muin J, Yang Quanhe, Moonesinghe Ramal   +2 more
doaj   +1 more source

Rare Variants of Putative Candidate Genes Associated With Sporadic Meniere's Disease in East Asian Population [PDF]

, 2020
Objectives: The cause of Meniere's disease (MD) is unclear but likely involves genetic and environmental factors. The aim of this study was to investigate the genetic basis underlying MD by screening putative candidate genes for MD.
Arweiler-Harbeck, Begovich, Brama, Cabrera, Campbell, de Lima, Doi, Dong, Eichler, Filipo, Flook, Foster, Frejo, Frejo, Frejo, Furuta, Gallego-Martinez, Gazquez, Gazquez, Girirajan, Greco, Hietikko, Huang, Kawaguchi, Khorsandi, Kim, Kimura, Klar, Koo, Lee, Lee, Lee, Lee, Lettre, Li, Li, Lien, Lien, Liew, Lopez-Escamez, Lopez-Escamez, Lopez-Escamez, Lopez-Escamez, Marcus, Martín-Sierra, Martín-Sierra, Melchiorri, Meng, Morrison, Mustelin, Nair, Nair, Nair, Nishio, Oliveira-Paula, Qin, Rasheed, Rauch, Recupero, Reich, Rentzsch, Requena, Requena, Requena, Requena, Roman-Naranjo, Saint Pierre, Schwanitz, Shu, Sun, Takumida, Teggi, Teggi, Teggi, Teranishi, Tilburg, Tomoda, Uchida, Vrabec, Yang, Yazdani, Yazdani   +81 more
core   +1 more source

COVID-19 and Genetic Variants of Protein Involved in the SARS-CoV-2 Entry into the Host Cells

Genes, 2020
The recent global COVID-19 public health emergency is caused by SARS-CoV-2 infections and can manifest extremely variable clinical symptoms. Host human genetic variability could influence susceptibility and response to infection.
A. Latini, E. Agolini, A. Novelli, P. Borgiani, Rosalinda Giannini, P. Gravina, A. Smarrazzo, M. Dauri, M. Andreoni, P. Rogliani, S. Bernardini, M. Helmer-Citterich, M. Biancolella, G. Novelli   +13 more
semanticscholar   +1 more source

HUMAN GENETIC VARIANTS AND THEIR ANALYSIS: CURRENT STATE AND FUTURE PERSPECTIVES

Slovenska pediatrija, 2020
Human genetic variants occur throughout the whole genome, both in the coding and non-coding regions. In addition to defining genetic diversity among individuals, they may, in some instances, cause various genetic diseases, many of which have their onset ...
Lara Slavec, Ksenija Geršak, Nataša Karas Kuželički, Katarina Trebušak Podkrajšek   +3 more
doaj   +1 more source

Mitochondrial genetic variants associated with bipolar disorder and Schizophrenia in a Japanese population

International Journal of Bipolar Disorders, 2023
Background Bipolar disorder (BD) and schizophrenia (SZ) are complex psychotic disorders (PSY), with both environmental and genetic factors including possible maternal inheritance playing a role.
Ryobu Tachi, Kazutaka Ohi, Daisuke Nishizawa, Midori Soda, Daisuke Fujikane, Junko Hasegawa, Ayumi Kuramitsu, Kentaro Takai, Yukimasa Muto, Shunsuke Sugiyama, Kiyoyuki Kitaichi, Ryota Hashimoto, Kazutaka Ikeda, Toshiki Shioiri   +13 more
doaj   +1 more source

Clinical application of high throughput molecular screening techniques for pharmacogenomics. [PDF]

, 2011
Genetic analysis is one of the fastest-growing areas of clinical diagnostics. Fortunately, as our knowledge of clinically relevant genetic variants rapidly expands, so does our ability to detect these variants in patient samples.
Schrijver, Iris, Wiita, Arun P
core   +1 more source

Hundreds of variants clustered in genomic loci and biological pathways affect human height [PDF]

, 2010
Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits ...
A Johansson, A Superti-Furga, Aila Rissanen, Aki S. Havulinna, Alan F. Wright, Alan R. Sanders, Alan R. Shuldiner, Albert Hofman, Albert Vernon Smith, Alessandro De Grandi, Alex N. Parker, Alice M. Arnold, Alistair S. Hall, Ana Marusic, Anders Hamsten, Andrea Maschio, Andreas Ziegler, Andres Metspalu, Andrew A. Hicks, Andrew C. Heath, Andrew P. Morris, Andrew R. Wood, Andrew T. Hattersley, André G. Uitterlinden, Anke Tönjes, Anna Dominiczak, Anna L. Dixon, Anna-Liisa Hartikainen, Anne U. Jackson, Anneli Pouta, Anthony J. Balmforth, Antonella Mulas, Antti Jula, Arthur W. Musk, Astrid Petersmann, AV Segrè, Ayellet V. Segrè, B Devlin, Barbara McKnight, Ben Oostra, Benjamin F. Voight, Brenda W. Penninx, Cameron Palmer, Carlo Rivolta, Carlos Iribarren, Caroline Hayward, Caroline S. Fox, Carsten Oliver Schmidt, CD Campbell, Cecilia M. Lindgren, Charles C. White, Christian Gieger, Christian Hengstenberg, Christopher J. O’Donnell, Claes Ohlsson, Constance Chen, Cornelia M. van Duijn, Cristen J. Willer, Dale R. Nyholt, Daniel Gudbjartsson, Daniel I. Chasman, Daniele Cusi, David J. Hunter, David P. Strachan, David S. Siscovick, David Schlessinger, Dawn Waterworth, DB Goldstein, Devin Absher, DF Gudbjartsson, Dominique J. Verlaan, Dorret I. Boomsma, Douglas F. Levinson, Eco J. C. Geus, Eero Kajantie, Eleanor Wheeler, Elin Grundberg, Elisabeth Widen, Elizabeth K. Speliotes, Elizabeth L. Altmaier, EM Kofoed, ER Neptune, Eric Boerwinkle, Eric E. Schadt, Erik Ingelsson, Erika Salvi, Eva Albrecht, F Galton, Fernando Rivadeneira, Florian Ernst, Francis S. Collins, Frank B. Hu, Fredrik Wiklund, G Lettre, G. Bragi Walters, G. Mark Lathrop, Gabrielle Boucher, Gert-Jan van Ommen, Gonneke Willemsen, Gonçalo R. Abecasis, Grant W. Montgomery, Gudmar Thorleifsson, Gudny Eiriksdottir, Guillaume Lettre, Guillaume Paré, H.-Erich Wichmann, Hana Lango Allen, Harry Campbell, Heather M. Stringham, Heikki V. Huikuri, Helene Alavere, Henrik Grönberg, Henry Völzke, Heribert Schunkert, Hugh Watkins, Ida Surakka, Igor Rudan, Inga Prokopenko, Ingrid B. Borecki, Inke R. König, Inês Barroso, Irene Pichler, Iris M. Heid, Ivana Kolcic, J Yang, Jaakko Kaprio, Jaakko Tuomilehto, Jaana Laitinen, Jacques S. Beckmann, James F. Wilson, Jan H. Smit, Jeanette Erdmann, Jeffrey R. O’Connell, Jennie Hui, Jennifer G. Sambrook, Jerome I. Rotter, JH Park, Jian Yang, Jianfeng Xu, Jianjun Liu, Jianxin Shi, Jian’an Luan, Jing Hua Zhao, Joel N. Hirschhorn, Johan G. Eriksson, Johannes Kettunen, John D. Rioux, John F. Peden, John P. Beilby, John R. B. Perry, John R. Thompson, Jonathan P. Tyrer, Jorma Viikari, Joshua C. Randall, Joshua W. Knowles, Jouke-Jan Hottenga, Joyce B. J. van Meurs, Ju-Hyun Park, Jubao Duan, Juha Sinisalo, Julius Suh Ngwa, K Estrada, KA Frazer, Karen L. Mohlke, Kari E. North, Kari Stefansson, Karol Estrada, Katja K. Aben, Ke Hao, Ken Sin Lo, Keri L. Monda, Kevin B. Jacobs, Kirsi H. Pietiläinen, Kristin G. Ardlie, L. Adrienne Cupples, LA Hindorff, Lachlan Coin, Lambertus Kiemeney, Larry D. Atwood, Laura Zagato, Lee M. Kaplan, Leena Peltonen, Leif C. Groop, Lenore J. Launer, Liesbeth Vandenput, Liming Liang, Lina Zgaga, Lorena Citterio, Lu Qi, Lyle J. Palmer, M Weinstein, M. Carola Zillikens, M. Juhani Junttila, Manfred Kayser, Manuela Uda, Mari Nelis, Mari-Liis Tammesoo, Marja-Liisa Lokki, Marjo-Riitta Jarvelin, Marjolein J. Peters, Mark I. McCarthy, Mark J. Caulfield, Markku Koiranen, Markku S. Nieminen, Markus Perola, Martin den Heijer, Martin Farrall, Martin Ridderstråle, Martina Müller, Mary F. Feitosa, Massimo Mangino, Matthew N. Cooper, Mattias Lorentzon, Michael A. Province, Michael Boehnke, Michael C. Turchin, Michael E. Goddard, Michael N. Weedon, Michael Preuss, Michael Stumvoll, Mika Kähönen, MN Weedon, MN Weedon, N Soranzo, Najaf Amin, Nancy L. Heard-Costa, Neil R. Robertson, Nelson B. Freimer, Nicholas G. Martin, Nicholas J. Wareham, Nicola Glorioso, Nicole L. Glazer, Nicole Soranzo, Nigel W. Rayner, Niina Pellikka, Nilanjan Chatterjee, Nilesh J. Samani, Olle Melander, Olli Raitakari, Ozren Polasek, Paavo Zitting, Pablo V. Gejman, Panos Deloukas, Patricia B. Munroe, Paul Elliott, Paul M. Ridker, Per Hall, Peter Almgren, Peter Kovacs, Peter Kraft, Peter M. Visscher, Peter P. Pramstaller, PM Visscher, Quince Gibson, RA Fisher, Rany M. Salem, Reedik Mägi, Richard B. Hayes, Richard N. Bergman, Robert C. Kaplan, Robert J. Weyant, Robert W. Lawrence, Roberto Elosua, Ruth J. F. Loos, S Raychaudhuri, S Sanna, Sailaja Vedantam, Samuli Ripatti, Sarah H. Wild, Sekar Kathiresan, Seppo Koskinen, Serena Sanna, Shamika Ketkar, Shaun Purcell, Shen Haiqing, SM Purcell, Sonja I. Berndt, Soumya Raychaudhuri, SP Dickson, Stefan Schreiber, Stephen J. Chanock, Suzanne Rafelt, Sven Bergmann, TA Manolio, Talin Haritunians, Tamara B. Harris, Teresa Ferreira, Terho Lehtimäki, Themistocles L. Assimes, Thomas Illig, Thomas Kocher, Thomas Meitinger, Thomas Quertermous, Thomas W. Winkler, Thor Aspelund, Timothy D. Spector, Timothy M. Frayling, Toby Johnson, Tom H. Mosley Jr, Tomi Pastinen, Tony Kwan, Tsegaselassie Workalemahu, Tuomas O. Kilpeläinen, Tushar Bhangale, Tõnu Esko, Ulf Gyllensten, Ulla Sovio, Unnur Thorsteinsdottir, Valgerdur Steinthorsdottir, Veikko Salomaa, Veronique Vitart, Vilmundur Gudnason, Vincent Mooser, Wendy L. McArdle, Willem H. Ouwehand, Wilmar Igl, Wolfgang Hoffman, Yurii S. Aulchenko, Zoltán Kutalik, Åsa Johansson   +319 more
core   +10 more sources

Pathogenesis of premature coronary artery disease: Focus on risk factors and genetic variants

Genes and Diseases, 2022
The development of premature coronary artery disease (PCAD) is dependent on both genetic predisposition and traditional risk factors. Strategies for unraveling the genetic basis of PCAD have evolved with the advent of modern technologies.
Haiming Wang, Zifan Liu, Junjie Shao, Min Jiang, Xuechun Lu, Lejian Lin, Lin Wang, Qiang Xu, Haomin Zhang, Xin Li, Jingjing Zhou, Yundai Chen, Ran Zhang   +12 more
doaj  

Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation. [PDF]

, 2019
Accumulating evidence from genome wide association studies (GWAS) suggests an abundance of shared genetic influences among complex human traits and disorders, such as mental disorders.
Andreassen, Ole A, Dale, Anders M, Djurovic, Srdjan, Fan, Chun Chieh, Frei, Oleksandr, Holland, Dominic, Maeland, Steffen, O'Connell, Kevin S, Shadrin, Alexey A, Smeland, Olav B, Thompson, Wesley K, Wang, Yunpeng   +11 more
core   +3 more sources

IndiGenomes: a comprehensive resource of genetic variants from over 1000 Indian genomes

Nucleic Acids Research, 2020
With the advent of next-generation sequencing, large-scale initiatives for mining whole genomes and exomes have been employed to better understand global or population-level genetic architecture.
Abhinav R Jain, R. Bhoyar, Kavita Pandhare, A. Mishra, D. Sharma, M. Imran, V. Senthivel, M. Divakar, M. Rophina, B. Jolly, Arushi Batra, Sumit Sharma, Sanjay Siwach, A. Jadhao, N. V. Palande, G. N. Jha, Nishat Ashrafi, P. Mishra, Vidhya A. K., Suman Jain, D. Dash, N. S. Kumar, Andrew Vanlallawma, Ranjan Jyoti Sarma, Lalchhandama Chhakchhuak, S. Kalyanaraman, Radha Mahadevan, Sunitha Kandasamy, Pabitha B. M., Raskin Erusan Rajagopal, Ezhil Ramya J., N. P., Anjali Bajaj, V. Gupta, Samatha Mathew, S. Goswami, Mohit Mangla, S. Prakash, Kandarp Joshi, Meyakumla, S. S., Devarshi Gajjar, R. Soraisham, R. Yadav, Yumnam Silla Devi, Aayush Gupta, M. Mukerji, S. Ramalingam, Binukumar B. K., V. Scaria, S. Sivasubbu   +50 more
semanticscholar   +1 more source