Results 71 to 80 of about 4,615,445 (390)

Integrative Genomic Analysis for the Discovery of Biomarkers in Prostate Cancer

Biomarker Insights, 2014
Genome-wide association studies (GWAS) have achieved great success in identifying single nucleotide polymorphisms (SNPs, herein called genetic variants) and genes associated with risk of developing prostate cancer. However, GWAS do not typically link the
Chindo Hicks, Tejaswi Koganti, Shankar Giri, Memory Tekere, Ritika Ramani, Jitsuda Sitthi-Amorn, Srinivasan Vijayakumar   +6 more
doaj   +1 more source

Accounting for Population Structure in Gene-by-Environment Interactions in Genome-Wide Association Studies Using Mixed Models. [PDF]

, 2016
Although genome-wide association studies (GWASs) have discovered numerous novel genetic variants associated with many complex traits and diseases, those genetic variants typically explain only a small fraction of phenotypic variance. Factors that account
Bilow, Michael, Eskin, Eleazar, Furlotte, Nick, He, Dan, Kostem, Emrah, Sul, Jae Hoon, Yang, Wen-Yun   +6 more
core   +4 more sources

Multivariable Mendelian Randomization: The Use of Pleiotropic Genetic Variants to Estimate Causal Effects

American Journal of Epidemiology, 2015
A conventional Mendelian randomization analysis assesses the causal effect of a risk factor on an outcome by using genetic variants that are solely associated with the risk factor of interest as instrumental variables. However, in some cases, such as the
S. Burgess, S. Thompson
semanticscholar   +1 more source

Genetic variants in major depression.

Novartis Foundation symposium, 2008
Major depression is one of the most common and most debilitating disorders in the world. A wealth of data indicate that additive genetic effects contribute to at least 30% of the variance in liability to major depression, yet attempts to identify the molecular basis of susceptibility using standard family based linkage and genetic association ...
Jonathan Flint, Sagiv Shifman, Richard Mott, Marcus R. Munafò, Marcus R. Munafò   +4 more
openaire   +3 more sources

Efficient inference for genetic association studies with multiple outcomes

, 2017
Combined inference for heterogeneous high-dimensional data is critical in modern biology, where clinical and various kinds of molecular data may be available from a single study.
Davison, Anthony C., Hager, Jörg, Irincheeva, Irina, Ruffieux, Hélène   +3 more
core   +1 more source

Genetic risk prediction of atrial fibrillation [PDF]

, 2017
Background—Atrial fibrillation (AF) has a substantial genetic basis. Identification of individuals at greatest AF risk could minimize the incidence of cardioembolic stroke. Methods—To determine whether genetic data can stratify risk for development of
Almgren, Peter, Alonso, Alvaro, Anderson, Christopher D., Benjamin, Emelia J, Chen, Lin Y., Darbar, Dawood, Ellinor, Patrick T, Engström, Gunnar, Ford, Ian, Furie, Karen L., Geelhoed, Bastiaan, Guo, Xiuqing, Heckbert, Susan R, Jukema, J. Wouter, Kathiresan, Sekar, Kolek, Matthew, Larson, Martin G., Lin, Henry J., Lubitz, Steven A, Lunetta, Kathryn L., Macfarlane, Peter W, Melander, Olle, on behalf of the AFGen Consortium, Psaty, Bruce M., Rienstra, Michiel, Roden, Dan M, Rosand, Jonathan, Roselli, Carolina, Rost, Natalia S., Rotter, Jerome I., Siland, Joylene E., Smith, Gustav G., Soliman, Elsayed Z, Sotoodehnia, Nona, Stott, David J., Taylor, Kent D, Teixeira, Pedro L., Trompet, Stella, van der Harst, Pim, Verweij, Niek, Weng, Lu Chen, Yao, Jie, Yin, Xiaoyan   +42 more
core   +10 more sources

Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses

Nature Genetics, 2016
Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet ...
A. Okbay, B. Baselmans, J. De Neve, P. Turley, M. Nivard, M. Fontana, S. Meddens, R. Linnér, C. A. Rietveld, J. Derringer, J. Gratten, James J. Lee, J. Liu, Ronald de Vlaming, T. Ahluwalia, Jadwiga Buchwald, A. Cavadino, A. Frazier-Wood, N. Furlotte, V. Garfield, M. H. Geisel, J. González, S. Haitjema, R. Karlsson, S. W. van der Laan, K. Ladwig, J. Lahti, S. J. van der Lee, P. Lind, Tian Liu, Lindsay K. Matteson, E. Mihailov, Michael B. Miller, C. Minică, I. Nolte, D. Mook-Kanamori, Peter J. van der Most, C. Oldmeadow, Yong Qian, O. Raitakari, R. Rawal, A. Realo, R. Rueedi, B. Schmidt, A. Smith, E. Stergiakouli, Toshiko Tanaka, K. Taylor, G. Thorleifsson, J. Wedenoja, J. Wellmann, H. Westra, Sara M. Willems, Wei Zhao, N. Amin, A. Bakshi, S. Bergmann, G. Bjornsdottir, P. Boyle, S. Cherney, S. Cox, G. Davies, O. Davis, Jun Ding, N. Direk, P. Eibich, R. Emeny, G. Fatemifar, J. Faul, L. Ferrucci, A. Forstner, C. Gieger, Richa Gupta, T. Harris, Juliette M. Harris, E. Holliday, J. Hottenga, P. D. De Jager, M. Kaakinen, E. Kajantie, V. Karhunen, I. Kolčić, M. Kumari, L. Launer, L. Franke, Ruifang Li-Gao, D. Liewald, M. Koini, A. Loukola, P. Marques-Vidal, G. Montgomery, M. Mosing, L. Paternoster, A. Pattie, K. Petrovic, L. Pulkki-Råback, L. Quaye, K. Räikkönen, I. Rudan, R. Scott, Jennifer A. Smith, A. Sutin, M. Trzaskowski, A. Vinkhuyzen, Lei Yu, D. Zabaneh, J. Attia, D. Bennett, K. Berger, L. Bertram, D. Boomsma, H. Snieder, Shun-Chiao Chang, F. Cucca, I. Deary, C. V. van Duijn, J. Eriksson, U. Bültmann, E. D. de Geus, P. Groenen, V. Gudnason, T. Hansen, C. Hartman, C. Haworth, C. Hayward, A. Heath, D. Hinds, E. Hyppönen, W. Iacono, M. Järvelin, K. Jöckel, J. Kaprio, S. Kardia, L. Keltikangas-Järvinen, P. Kraft, L. Kubzansky, T. Lehtimäki, P. Magnusson, N. Martin, M. McGue, A. Metspalu, M. Mills, R. de Mutsert, A. Oldehinkel, G. Pasterkamp, N. Pedersen, R. Plomin, O. Polašek, C. Power, S. Rich, F. Rosendaal, H. D. den Ruijter, D. Schlessinger, H. Schmidt, R. Svento, R. Schmidt, B. Alizadeh, T. Sørensen, T. Spector, J. Starr, K. Stefánsson, A. Steptoe, A. Terracciano, U. Thorsteinsdóttir, A. Thurik, N. Timpson, H. Tiemeier, A. Uitterlinden, P. Vollenweider, G. Wagner, D. Weir, Jian Yang, D. Conley, G. Smith, A. Hofman, M. Johannesson, David Laibson, S. Medland, M. Meyer, Joseph K. Pickrell, T. Esko, R. Krueger, J. Beauchamp, P. Koellinger, D. Benjamin, M. Bartels, D. Cesarini   +186 more
semanticscholar   +1 more source

Schizophrenia genetic variants are not associated with intelligence [PDF]

Psychological Medicine, 2013
BackgroundSchizophrenia is associated with lower pre-morbid intelligence (IQ) in addition to (pre-morbid) cognitive decline. Both schizophrenia and IQ are highly heritable traits. Therefore, we hypothesized that genetic variants associated with schizophrenia, including copy number variants (CNVs) and a polygenic schizophrenia (risk) score (PSS), may ...
van Scheltinga, AF, Bakker, SC, van Haren, NE, Derks, EM, Buizer Voskamp, JE, Cahn, W, Ripke, S, Ripke, S, Sanders, A, Kendler, K, Levinson, D, Sklar, P, Holmans, P, Lin, D., Duan, J, Ophoff, R, Andreassen, O, Scolnick, E, Cichon, S, St Clair, D, Corvin, A, Gurling, H, Werge, T, Rujescu, D, Blackwood, D, Pato, C, Malhotra, A, Purcell, S, Dudbridge, F, Neale, B, Rossin, L, Visscher, P, Posthuma, D, Ruderfer, D, Fanous, A, Stefansson, H, Steinberg, S, Mowry, B, Golimbet, V, De, Hert, M, Jonsson, E, Bitter, I, Pietilainen, O, Collier, D, TOSATO, Sarah, Agartz, I, Albus, M, Alexander, M, Amdur, R, Amin, F, Bass, N, Bergen, S, Black, D, Børglum, A, Brown, M, Bruggeman, R, Buccola, N, Byerley, W, Cahn, W, Cantor, R, Carr, V, Catts, S, Choudhury, K, Cloninger, C, Cormican, P, Craddock, N, Danoy, P, Datta, S, de, Haan, L, Demontis, D, Dikeos, D, Djurovic, S, Donnelly, P, Donohoe, G, Duong, L, Dwyer, S, Fink Jensen, A, Freedman, R, Freimer, N, Friedl, M, Georgieva, L, Giegling, I, Gill, M, Glenthøj, B, Godard, S, Hamshere, M, Hansen, M, Hansen, T, Hartmann, A, Henskens, F, Hougaard, D, Hultman, C, Ingason, A, Jablensky, A, Jakobsen, K, Jay, M, Jurgens, G, Kahn, R, Keller, M, Kenis, G, Kenny, E, Kim, Y, Kirov, G, Konnerth, H, Konte, B, Krabbendam, L, Krasucki, R, Lasseter, V, Laurent, C, Lawrence, J, Lencz, T, Lerer, F, Liang, K, Lichtenstein, P, Lieberman, J, Linszen, D, Lonnqvist, J, Loughland, C, Maclean, A, Maher, B, Maier, W, Mallet, J, Malloy, P, Mattheisen, M, Mattingsdal, M, McGhee, K, McGrath, J, McIntosh, A, McLean, D, McQuillin, A, Melle, I, Michie, P, Milanova, V, Morris, D, Mors, O, Mortensen, P, Moskvina, V, Muglia, P, Myin Germeys, I, Nertney, D, Nestadt, G, Nielsen, J, Nikolov, I, Nordentoft, M, Norton, N, Nothen, M, O'Dushlaine, C, Olincy, A, Olsen, L, O'Neill, F, Ørntoft, T, Owen, M, Pantelis, C, Papadimitriou, G, Pato, M, Peltonen, L, Petursson, H, Pickard, B, Pimm, J, Pulver, A, Puri, V, Quested, D, Quinn, E, Rasmussen, H, Rethelyi, JM, Ribble, R, Rietschel, M, Riley, B, RUGGERI, Mirella, Schall, U, Schulze, T, Schwab, S, Scott, R, Shi, J, Sigurdsson, E, Silverman, J, Spencer, C, Stefansson, K, Strange, A, Strengman, E, Stroup, T, Suvisaari, J, Terenius, L, Thirumalai, S, Thygesen, J, Timm, S, Toncheva, D, van den Oord, E, van Os, J, van Winkel, R, Veldink, J, Walsh, D, Wang, A, Wiersma, D, Wildenauer, D, Williams, H, Williams, N, Wormley, B, Zammit, S, O'Donovan, M   +201 more
openaire   +5 more sources

Interaction of Insulin Resistance and Related Genetic Variants With Triglyceride-Associated Genetic Variants [PDF]

Circulation: Cardiovascular Genetics, 2016
Background— Several studies suggest that some triglyceride-associated single-nucleotide polymorphisms (SNPs) have pleiotropic and opposite effects on glycemic traits. This potentially implicates them in pathways such as de novo lipogenesis, which is presumably upregulated in the context of insulin resistance.
Amit Arora, Yann C. Klimentidis
openaire   +3 more sources

Geographic variation in walking activity in the red flour beetle Tribolium castaneum

Population Ecology, EarlyView.
This study examined whether there is geographic variation in field populations, focusing on the moving activity in the red flour beetle Tribolium castaneum. Results showed significant differences in moving activity among field populations but no correlation with latitude or meteorological factors.
Kentarou Matsumura
wiley   +1 more source