Results 121 to 130 of about 2,064,271 (324)

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Overcoming maladaptive plasticity through plastic compensation

Current Zoology, 2013
Most species evolve within fluctuating environments, and have developed adaptations to meet the challenges posed by environmental heterogeneity. One such adaptation is phenotypic plasticity, or the ability of a single genotype to produce multiple ...
Matthew R.J. MORRIS, Sean M. ROGERS
doaj  

Populationsgenetische Differenzierung beim Eichenwickler (Tortrix viridana L.) und seiner Wirtspflanze (Quercus robur L.) anhand nukleärer Genmarker [PDF]

, 2008
In Western Europe pedunculate oak (Quercus robur L.) is the forest tree with the highest number of phytophagous insect species (Yela & Lawton 1997). One of these, the green oak leaf roller Tortrix viridana L.
Schröder, Hilke
core  

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Identifying Genetic Variants in Patients With Cefaclor‐Induced Anaphylaxis Using Human Leukocyte Antigen Typing and Whole‐Exome Sequencing

Clinical and Translational Allergy
Background Cefaclor is a commonly prescribed β‐lactam antibiotic and a known major cause of immediate‐type drug hypersensitivity in Korea. However, its genetic risk factors remain poorly understood.
Sung‐Ryeol Kim, Da Eun Lee, Hyun Young Jung, In‐Wha Kim, Hye‐Ryun Kang, Kyung Hee Park, Jung‐Won Park, Jung‐Mi Oh, Jae‐Hyun Lee   +8 more
doaj   +1 more source

Random regressions models to describe the genetic variation of milk yield over multiple parities in Buffaloes [PDF]

, 2007
P.M. Galeazzi, Josineudson Augusto II de Vasconcelos Silva, R.C. Sesana, Leonardo de Oliveira Seno, Rusbel Raúl Aspilcueta Borquis, A.L.F. Lima, Humberto Tonhati   +6 more
openalex   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Genetic architecture of heritable leaf microbes

Microbiology Spectrum
Host-associated microbiomes are shaped by both their environment and host genetics, and often impact host performance. The scale of host genetic variation important to microbes is largely unknown yet fundamental to the community assembly of host ...
Julia A. Boyle, Megan E. Frederickson, John R. Stinchcombe   +2 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source