Results 111 to 120 of about 4,640,461 (294)

THE GENETICS OF ELECTROPHORETIC VARIATION [PDF]

Genetics, 1979
J A, Coyne, W F, Eanes, R C, Lewontin
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Phylogeny of the members of the genus Alburnoides in Iran using COI gene

‬‭Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 2019
Up to now, twelve species of the genus Alburnoides belonged to Cyprinidae have been described from Iranian inland water solely based on the morphological characteristics.
S. Eagderi; A. Jouladeh-Roudbar; J. Imani Harsini; M. Rostami
doaj  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Intra-individual variation in energy requirement and its genetic significance

, 1997
It is generally assumed in nutrition studies that the energy requirement of an individual is fixed and that any variation from day to day is negligible relative to variation between individuals of the same age, sex and body weight.
Narain, Prem, Sukhatme, P. V.
core   +2 more sources

Identifying Genetic Variants in Patients With Cefaclor‐Induced Anaphylaxis Using Human Leukocyte Antigen Typing and Whole‐Exome Sequencing

Clinical and Translational Allergy
Background Cefaclor is a commonly prescribed β‐lactam antibiotic and a known major cause of immediate‐type drug hypersensitivity in Korea. However, its genetic risk factors remain poorly understood.
Sung‐Ryeol Kim, Da Eun Lee, Hyun Young Jung, In‐Wha Kim, Hye‐Ryun Kang, Kyung Hee Park, Jung‐Won Park, Jung‐Mi Oh, Jae‐Hyun Lee   +8 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Overcoming maladaptive plasticity through plastic compensation

Current Zoology, 2013
Most species evolve within fluctuating environments, and have developed adaptations to meet the challenges posed by environmental heterogeneity. One such adaptation is phenotypic plasticity, or the ability of a single genotype to produce multiple ...
Matthew R.J. MORRIS, Sean M. ROGERS
doaj  

Differentiation of free-ranging chicken using discriminant analysis of phenotypic traits

Revista Brasileira de Zootecnia
In this study, we investigated the differentiation of five different chicken ecotypes - Center, North, South, West, and East - of Saudi Arabia using discriminate analysis. The analysis was based on nine important morphological and phenotypic traits: body
Raed M. Al-Atiyat, Riyadh S. Aljumaah, Alaeldein M. Abudabos, Masoud N. Alotybi, Raafat M. Harron, Abdulaziz S. Algawaan, Hassan S. Aljooan   +6 more
doaj   +1 more source