Results 11 to 20 of about 1,970,763 (233)

Genetic variation in healthy oldest-old.

PLoS ONE, 2009
Individuals who live to 85 and beyond without developing major age-related diseases may achieve this, in part, by lacking disease susceptibility factors, or by possessing resistance factors that enhance their ability to avoid disease and prolong lifespan.
Julius Halaschek-Wiener, Mahsa Amirabbasi-Beik, Nasim Monfared, Markus Pieczyk, Christian Sailer, Anita Kollar, Ruth Thomas, Georgios Agalaridis, So Yamada, Lisa Oliveira, Jennifer A Collins, Graydon Meneilly, Marco A Marra, Kenneth M Madden, Nhu D Le, Joseph M Connors, Angela R Brooks-Wilson   +16 more
doaj   +6 more sources

Genetic Variation of PPARs [PDF]

PPAR Research, 2009
Welcome to this special issue of PPAR Research dedicated to the “Genetic Variation of PPARs.” Since PPARs are nuclear transcription factors regulating multiple genes involved in energy production, glucose and lipid metabolism, polymorphisms in these receptors may influence the pathology of numerous diseases including obesity, diabetes, atherosclerosis,
Marie-Claude Vohl, Mostafa Badr, Stefan Wieczorek   +2 more
doaj   +4 more sources

Genetic Variation and Atherosclerosis [PDF]

Current Genomics, 2008
A family history of atherosclerosis is independently associated with an increased incidence of cardiovascular events. The genetic factors underlying the importance of inheritance in atherosclerosis are starting to be understood. Genetic variation, such as mutations or common polymorphisms has been shown to be involved in modulation of a range of risk ...
Biros, Erik, Karan, Mirko, Golledge, Jonathan   +2 more
openaire   +4 more sources

Cryptic genetic variation [PDF]

Current Biology, 2008
What is cryptic genetic variation? Cryptic genetic variation refers to unexpressed, bottled-up genetic potential. It is not normally seen, but is expressed under abnormal conditions such as in a new environment or a different genetic background.
Gibson Greg, Reed, Laura K.
openaire   +4 more sources

Genetic variation in the zebrafish [PDF]

Genome Research, 2006
Although zebrafish was introduced as a laboratory model organism several decades ago and now serves as a primary model for developmental biology, there is only limited data on its genetic variation. An establishment of a dense polymorphism map becomes a requirement for effective linkage analysis and cloning approaches in zebrafish. By comparing ESTs to
Guryev, Victor, Koudijs, Marco J., Berezikov, Eugene, Johnson, Stephen L., Plasterk, Ronald H.A., Van Eeden, Fredericus J.M., Cuppen, Edwin   +6 more
openaire   +5 more sources

Phenotypic robustness can increase phenotypic variability after non-genetic perturbations in gene regulatory circuits [PDF]

, 2010
Non-genetic perturbations, such as environmental change or developmental noise, can induce novel phenotypes. If an induced phenotype confers a fitness advantage, selection may promote its genetic stabilization. Non-genetic perturbations can thus initiate
Ancel, Aubret, Azevedo, Bergman, Ciliberti, Ciliberti, Cooper, Davidson, de Jong, de Visser, Draghi, Draghi, Eldar, Elowitz, Espinosa-Soto, Espinosa-Soto, Ferrada, Fraser, Gibson, Gilbert, Gomez-Mestre, Griswold, Hall, Hermisson, Kim, Kimbrell, Kondrashov, Lande, Ledon-Rettig, Lehner, Levy, Lipman, Martin, Martin, Masel, Masel, Masel, McAdams, Meiklejohn, Moczek, Newman, Orr, Palmer, Palmer, Pigliucci, Pigliucci, Price, Proulx, Prud'homme, Raj, Rice, Roberts, Rodrigues, Rutherford, Schmalhausen, Schultes, Schuster, Shubin, Siegal, Snell-Rood, Sollars, Suzuki, Tirosh, van Nimwegen, Waddington, Waddington, Wagner, Wagner, Wagner, Wagner, Wagner, West-Eberhard, West-Eberhard, Wray   +73 more
core   +3 more sources

Using eQTL weights to improve power for genome-wide association studies: a genetic study of childhood asthma

Frontiers in Genetics, 2013
Increasing evidence suggests that single nucleotide polymorphisms (SNPs) associated with complex traits are more likely to be expression quantitative trait loci (eQTLs).
Lin eLi, Michael eKabesch, Emmanuelle eBouzigon, Emmanuelle eBouzigon, Florence eDemenais, Florence eDemenais, Martin eFarrall, Miriam F. Moffatt, Xihong eLin, Liming eLiang, Liming eLiang   +10 more
doaj   +1 more source

Network-assisted analysis of GWAS data identifies a functionally-relevant gene module for childhood-onset asthma

Scientific Reports, 2017
The number of genetic factors associated with asthma remains limited. To identify new genes with an undetected individual effect but collectively influencing asthma risk, we conducted a network-assisted analysis that integrates outcomes of genome-wide ...
Y. Liu, M. Brossard, C. Sarnowski, A. Vaysse, M. Moffatt, P. Margaritte-Jeannin, F. Llinares-López, M. H. Dizier, M. Lathrop, W. Cookson, E. Bouzigon, F. Demenais   +11 more
doaj   +1 more source

Reduced Neuronal Transcription of Escargot, the Drosophila Gene Encoding a Snail-Type Transcription Factor, Promotes Longevity

Frontiers in Genetics, 2018
In recent years, several genes involved in complex neuron specification networks have been shown to control life span. However, information on these genes is scattered, and studies to discover new neuronal genes and gene cascades contributing to life ...
Alexander V. Symonenko, Natalia V. Roshina, Natalia V. Roshina, Anna V. Krementsova, Anna V. Krementsova, Elena G. Pasyukova   +5 more
doaj   +1 more source

Genetic variability for vigor and yield of robusta coffee (Coffea canephora) clones in Ghana

Heliyon, 2022
Effectiveness of plant improvement programs, especially in perennial crops like coffee, may be improved by knowing the level of genetic variation which exist within a breeding population coupled with the knowledge of estimates of genetic parameters for ...
Abraham Akpertey, Esther Anim-Kwapong, Paul Kwasi Krah Adu-Gyamfi, Atta Ofori   +3 more
doaj   +1 more source