Phenotypic robustness can increase phenotypic variability after non-genetic perturbations in gene regulatory circuits [PDF]
, 2010 Non-genetic perturbations, such as environmental change or developmental noise, can induce novel phenotypes. If an induced phenotype confers a fitness advantage, selection may promote its genetic stabilization. Non-genetic perturbations can thus initiate
Ancel +73 more
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Wild worm embryogenesis harbors ubiquitous polygenic modifier variation
eLife, 2015 Embryogenesis is an essential and stereotypic process that nevertheless evolves among species. Its essentiality may favor the accumulation of cryptic genetic variation (CGV) that has no effect in the wild-type but that enhances or suppresses the effects ...
Annalise B Paaby +5 more
doaj +1 more source
Benefits of host genetic diversity for resistance to infection depend on parasite diversity [PDF]
, 2010 Host populations with high genetic diversity are predicted to have lower levels of infection prevalence. This theory assumes that host genetic diversity results in variation in susceptibility and that parasites exhibit variation in infectivity. Empirical
Ebert, D., Ganz, H.
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Genetic analysis of environmental variation [PDF]
Genetics Research, 2010 SummaryEnvironmental variation (VE) in a quantitative trait – variation in phenotype that cannot be explained by genetic variation or identifiable genetic differences – can be regarded as being under some degree of genetic control. Such variation may be either between repeated expressions of the same trait within individuals (e.g. for bilateral traits),
Hill, W.G., Mulder, H.A.
openaire +3 more sources
Impact of pharmacogenetics on aspirin resistance: a systematic review
Arquivos de Neuro-Psiquiatria, 2023 Background Pharmacogenetics promises better control of diseases such as cardiovascular disease (CVD). Acetylsalicylic acid, aspirin, prevents the formation of an activating agent of platelet aggregation and vasoconstriction, and it is used to prevent CVD.
Gustavo Figueiredo da Silva +3 more
doaj +1 more source
Genetics of trans-regulatory variation in gene expression
eLife, 2018 Heritable variation in gene expression forms a crucial bridge between genomic variation and the biology of many traits. However, most expression quantitative trait loci (eQTLs) remain unidentified.
Frank Wolfgang Albert +4 more
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Cirsium species show disparity in patterns of genetic variation at their range-edge, despite similar patterns of reproduction and isolation [PDF]
, 2003 Genetic variation was assessed across the UK geographical range of Cirsium acaule and Cirsium heterophyllum. A decline in genetic diversity and increase in population divergence approaching the range edge of these species was predicted based on parallel ...
Alistair S. Jump +39 more
core +1 more source
Asian Journal of Pharmaceutical Sciences, 2022 Extracellular vesicles (EVs)-based cell-free therapy, particularly stem cell-derived extracellular vesicles (SC-EVs), offers new insights into treating a series of neurological disorders and becomes a promising candidate for alternative stem cell ...
Shilin Jin +7 more
doaj
A major genetic locus in Trypanosoma brucei is a determinant of host pathology [PDF]
, 2009 The progression and variation of pathology during infections can be due to components from both host or pathogen, and/or the interaction between them. The influence of host genetic variation on disease pathology during infections with trypanosomes has ...
A Beckers +55 more
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Assessment of Genetic Diversity and Conservation in South African Indigenous Goat Ecotypes: A Review
Animals, 2022 Goats were amongst the first livestock to be domesticated more than 10,000 years ago for their meat, milk, skin, and fiber. They were introduced to Southern Africa by migrating nations from Central Africa to the south.
Aletta Matshidiso Magoro +3 more
doaj +1 more source