Results 31 to 40 of about 2,064,271 (324)

The effect of genomic information on optimal contribution selection in livestock breeding programs [PDF]

, 2013
BACKGROUND: Long-term benefits in animal breeding programs require that increases in genetic merit be balanced with the need to maintain diversity (lost due to inbreeding). This can be achieved by using optimal contribution selection. The availability of
Clark, Samuel A, Hickey, John M, Kinghorn, Brian P, van der Werf, Julius Hj   +3 more
core   +6 more sources

Visualizing genetic constraints [PDF]

, 2013
Principal Components Analysis (PCA) is a common way to study the sources of variation in a high-dimensional data set. Typically, the leading principal components are used to understand the variation in the data or to reduce the dimension of the data for ...
Gaydos, Travis L., Heckman, Nancy E., Kingsolver, Joel, Kirkpatrick, Mark, Marron, J. S., Schmitt, Johanna, Stinchcombe, J. R.   +6 more
core   +3 more sources

Statistics of selectively neutral genetic variation

, 2001
Random models of evolution are instrumental in extracting rates of microscopic evolutionary mechanisms from empirical observations on genetic variation in genome sequences.
A. H. D. Brown, B. Haubold, C. Wiuf, E. S. Lander, G. A. Watterson, G. P. Patil, J. C. Venter, J. F. C. Kingman, J. Maynard Smith, K. E. Dingle, M. Bahlo, M. C. J. Maiden, M. Kimura, M. Kreitman, N. Takahata, P. A. Fuerst, P. Donnelly, R. Arratia, R. R. Hudson, T. Ohta, Th. Wiehe, V. Souza   +21 more
core   +1 more source

Ironing out the details: Untangling dietary iron and genetic background in diabetes [PDF]

, 2018
The search for genetic risk factors in type-II diabetes has been hindered by a failure to consider dietary variables. Dietary nutrients impact metabolic disease risk and severity and are essential to maintaining metabolic health.
Lawson, Heather A, Miranda, Mario A
core   +2 more sources

Oracle selection provides insight into how far off practice is from Utopia in plant breeding

Frontiers in Plant Science, 2023
Since the introduction of genomic selection in plant breeding, high genetic gains have been realized in different plant breeding programs. Various methods based on genomic estimated breeding values (GEBVs) for selecting parental lines that maximize the ...
David Vanavermaete, Steven Maenhout, Jan Fostier, Bernard De Baets   +3 more
doaj   +1 more source

Assessment of the dynamics of microparasite infections in genetically homogeneous and heterogeneous populations using a stochastic epidemic model [PDF]

, 2008
The aim of this paper was to explore the effect of genetic heterogeneity in host resistance to infection on the population-level risks and outcomes of epidemics.
Bishop, S. C., Nath, M., Woolliams, J. A.   +2 more
core   +1 more source

The role of mutation rate variation and genetic diversity in the architecture of human disease [PDF]

, 2013
Background We have investigated the role that the mutation rate and the structure of genetic variation at a locus play in determining whether a gene is involved in disease.
A Hodgkinson, A Hodgkinson, A Kong, Adam Eyre-Walker, B Charlesworth, B Charlesworth, C Park, CJ Pink, CL Chen, FA Kondrashov, G McVicker, H Ellegren, H Huang, I Hellmann, I Hellmann, I. King Jordan, J Maynard Smith, JA Stamatoyannopoulos, JJ Michaelson, KH Wolfe, L Duret, MJ Lercher, MT Maurano, MW Nachman, NG Smith, R Blekhman, RS Hansen, S Tyekucheva, TI Gossmann, Ying Chen Eyre-Walker   +29 more
core   +10 more sources

The association between single nucleotide polymorphism in vitamin D receptor and calcium oxalate urolithiasis in dogs

Journal of Veterinary Internal Medicine, 2021
Background Polymorphisms of the vitamin D receptor (VDR) are associated with calcium oxalate (CaOx) nephrolithiasis in humans. Objectives To investigate the association between VDR polymorphisms and susceptibility to CaOx urolithiasis in dogs.
Sumonwan Chamsuwan, Kris Angkanaporn, Thasinas Dissayabutra, Natthaya Chuaypen, Chollada Buranakarl   +4 more
doaj   +1 more source

The Genetic Basis of Mutation Rate Variation in Yeast. [PDF]

, 2018
Mutations are the root source of genetic variation and underlie the process of evolution. Although the rates at which mutations occur vary considerably between species, little is known about differences within species, or the genetic and molecular basis ...
Bloom, Joshua S, Gou, Liangke, Kruglyak, Leonid   +2 more
core   +1 more source

Genetic Variation and Atherosclerosis [PDF]

Current Genomics, 2008
A family history of atherosclerosis is independently associated with an increased incidence of cardiovascular events. The genetic factors underlying the importance of inheritance in atherosclerosis are starting to be understood. Genetic variation, such as mutations or common polymorphisms has been shown to be involved in modulation of a range of risk ...
Biros, Erik, Karan, Mirko, Golledge, Jonathan   +2 more
openaire   +3 more sources