Results 101 to 110 of about 617,752 (328)

An efficient CRISPR vector toolbox for engineering large deletions in Arabidopsis thaliana

Plant Methods, 2018
Background Our knowledge of natural genetic variation is increasing at an extremely rapid pace, affording an opportunity to come to a much richer understanding of how effects of specific genes are dependent on the genetic background.
Rui Wu, Miriam Lucke, Yun-ting Jang, Wangsheng Zhu, Efthymia Symeonidi, Congmao Wang, Joffrey Fitz, Wanyan Xi, Rebecca Schwab, Detlef Weigel   +9 more
doaj   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Schistosomiasis: Basic requirements for the development of a subunit vaccine, using genetic vectors. [PDF]

EBioMedicine, 2022
Ahmad G.
europepmc   +1 more source

Research advances in replication-deficient viral vector vaccines

Frontiers in Veterinary Science
In recent years, replication-deficient viral vector vaccines have attracted much attention in the field of vaccine research and development due to their high safety and immunogenicity.
Junna Wang, Junna Wang, Jin Cui, Guoxin Li, Lingxue Yu, Lingxue Yu   +5 more
doaj   +1 more source

(Non)Parallel Evolution [PDF]

, 2018
Parallel evolution across replicate populations has provided evolutionary biologists with iconic examples of adaptation. When multiple populations colonize seemingly similar habitats, they may evolve similar genes, traits, or functions.
Barrett, Rowan DH, Bolnick, Daniel I, Oke, Krista B, Rennison, Diana J, Stuart, Yoel E   +4 more
core  

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

Efficient Gene Targeting Mediated by Adeno-Associated Virus and DNA Double-Strand Breaks [PDF]

, 2003
Gene targeting is the in situ manipulation of the sequence of an endogenous gene by the introduction of homologous exogenous DNA. Presently, the rate of gene targeting is too low for it to be broadly used in mammalian somatic cell genetics or to cure ...
Baltimore, David, Cathomen, Toni, Porteus, Matthew H., Weitzman, Matthew D.   +3 more
core  

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

A simple and efficient CRISPR/Cas9 system permits ultra-multiplex genome editing in plants

Crop Journal
The development and maturation of the CRISPR/Cas genome editing system provides a valuable tool for plant functional genomics and genetic improvement.
Suting Wu, Htin Kyaw, Zhijun Tong, Yirong Yang, Zhiwei Wang, Liying Zhang, Lihua Deng, Zhiguo Zhang, Bingguang Xiao, William Paul Quick, Tiegang Lu, Guoying Xiao, Guannan Qin, Xue’an Cui   +13 more
doaj   +1 more source

Particle Swarm Optimization Framework for Low Power Testing of VLSI Circuits

, 2011
Power dissipation in sequential circuits is due to increased toggling count of Circuit under Test, which depends upon test vectors applied. If successive test vectors sequences have more toggling nature then it is sure that toggling rate of flip flops is
Khosla, Arun, Narang, Sukhleen Bindra, Singh, Balwnder   +2 more
core   +2 more sources