Results 121 to 130 of about 617,752 (328)
The Evolution of Adenoviral Vectors through Genetic and Chemical Surface Modifications
Viruses, 2014 A long time has passed since the first clinical trial with adenoviral (Ad) vectors. Despite being very promising, Ad vectors soon revealed their limitations in human clinical trials.
Cristian Capasso +3 more
doaj +1 more source
Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs
Molecular Oncology, EarlyView.In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza +3 more
wiley +1 more source
Integrating Retroviral Cassette Extends Gene Delivery of HSV-1 Expression Vectors to Dividing Cells
BioTechniques, 2001 Retroviral vectors have long been used in a wide variety of gene transfer applications but have certain drawbacks, such as small cargo size, limited tropism, and low titers.
Pablo de Felipe +3 more
doaj +1 more source
The evolution and genetics of vector competence in mosquito disease vectors
, 2013 Vector competence is a complex characteristic which governs an insect's ability to acquire, support the development and transmit a parasite from one host to another. It influences variation in disease transmission among mosquito populations, hence affecting disease epidemiology.
openaire +2 more sources
Molecular Oncology, EarlyView.RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha +10 more
wiley +1 more source
Molecular phylogeny of the Anopheles gambiae complex suggests genetic introgression between principal malaria vectors. [PDF]
, 1994 Nora J. Besansky +5 more
openalex +1 more source
Chinese Journal of Lung Cancer, 2008 Background and objective The drug resistance to chemotherapeutics is one of the important causes of low survival rate of lung cancer patients.
Xuejun LI, Heping YANG, Xiangdong ZHOU
doaj
Analysis of attractor distances in Random Boolean Networks
, 2010 We study the properties of the distance between attractors in Random Boolean Networks, a prominent model of genetic regulatory networks. We define three distance measures, upon which attractor distance matrices are constructed and their main statistic ...
Benedettini, Stefano +3 more
core +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Characterization of CD8+ cytotoxic T-lymphocyte responses after genetic immunization with retrovirus vectors expressing different forms of the hepatitis B virus core and e antigens [PDF]
, 1997 Kay Townsend +10 more
openalex +1 more source