Potent Vaccine Therapy with Dendritic Cells Genetically Modified by the Gene-Silencing-Resistant Retroviral Vector GCDNsap [PDF]
, 2005 Tsukasa Nabekura +4 more
openalex +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
The Evolution of Adenoviral Vectors through Genetic and Chemical Surface Modifications
Viruses, 2014 A long time has passed since the first clinical trial with adenoviral (Ad) vectors. Despite being very promising, Ad vectors soon revealed their limitations in human clinical trials.
Cristian Capasso +3 more
doaj +1 more source
Low Genetic Diversity of Vector-Borne Haemoparasites in Dogs and Their Ticks Revealed Local and Long-Range Transmission in Peninsular Malaysia [PDF]
, 2023 Quincie Sipin +4 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Chinese Journal of Lung Cancer, 2008 Background and objective The drug resistance to chemotherapeutics is one of the important causes of low survival rate of lung cancer patients.
Xuejun LI, Heping YANG, Xiangdong ZHOU
doaj
818. Efficient Induction of Humoral and Cellular Immune Responses Against Her-2/neu by Combination of Naked DNA and Adenoviral Vectors Expressing Genetically Engineered Her-2/ neu [PDF]
, 2010 openalex +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Tissue-Specific Ferritin- and GFP-Based Genetic Vectors Visualize Neurons by MRI in the Intact and Post-Ischemic Rat Brain. [PDF]
Int J Mol Sci, 2020 Khodanovich MY +15 more
europepmc +1 more source