Results 131 to 140 of about 4,784,986 (369)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Fluorescently Labeled Adenovirus with pIX-EGFP for Vector Detection
Molecular Imaging, 2004 Adenoviruses are extensively studied in terms of their use as gene therapy vectors and pathogenesis. These vectors have been targeted on both transcriptional and transductional levels to achieve cell-specific gene delivery.
Long P. Le +5 more
doaj +1 more source
The art of vector engineering: towards the construction of next‐generation genetic tools
Microbial Biotechnology, 2018 When recombinant DNA technology was developed more than 40 years ago, no one could have imagined the impact it would have on both society and the scientific community. In the field of genetic engineering, the most important tool developed was the plasmid
L. C. Nora +6 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Genetic Targeting of Adenoviral Vectors
Molecular Therapy, 2000 Krasnykh, V N +2 more
openaire +4 more sources
Metabolic Engineering Communications, 2016 Clostridium thermocellum is a leading candidate for the consolidated bioprocessing of lignocellulosic biomass for the production of fuels and chemicals.
Joseph Groom +5 more
doaj +1 more source
737. Development of a Feline Immunodeficiency Virus-Based Lentiviral Vector for Genetic Modification of CNS Neurons [PDF]
, 2004 Qinshan Teng +7 more
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Integrating Retroviral Cassette Extends Gene Delivery of HSV-1 Expression Vectors to Dividing Cells
BioTechniques, 2001 Retroviral vectors have long been used in a wide variety of gene transfer applications but have certain drawbacks, such as small cargo size, limited tropism, and low titers.
Pablo de Felipe +3 more
doaj +1 more source
818. Efficient Induction of Humoral and Cellular Immune Responses Against Her-2/neu by Combination of Naked DNA and Adenoviral Vectors Expressing Genetically Engineered Her-2/ neu [PDF]
, 2010 openalex +1 more source